Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsSinan Guloksuz, MD, PhD
Associate Professor Adjunct in PsychiatryAbout
Research
Publications
2026
Shared genetic architecture between Alzheimer’s disease and brain morphology
Wu X, Shadrin A, Blokland G, Guloksuz S, Andreassen O, Linden D, van der Meer D. Shared genetic architecture between Alzheimer’s disease and brain morphology. Alzheimer's Research & Therapy 2026 PMID: 42271432, DOI: 10.1186/s13195-026-02105-5.Peer-Reviewed Original ResearchLate-onset Alzheimer's diseaseLinkage disequilibrium score regressionGlobal genetic correlationsGenetic architecturePolygenic overlapPolygenic scoresMorphological traitsBivariate causal mixture modelGenome-wide association study summary statisticsGenetic correlationsGenetic driversLocal genetic correlationCellular component organizationAlzheimer's diseaseDrivers of neurodegenerationLocus levelWhole genomeShared lociConjunctional FDRGenotype dataGenetic relationshipsLocal analysisGenetic variantsShared genesCellular developmentQuality over quantity: association between autistic traits and daily-life social interactions in adolescents and young adults from the TwinssCan cohort
Fusar-Poli L, Prachason T, Brondino N, Nola M, Lin B, Pries L, Doğan M, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Politi P, Guloksuz S. Quality over quantity: association between autistic traits and daily-life social interactions in adolescents and young adults from the TwinssCan cohort. CNS Spectrums 2026, 31: e14. PMID: 42223028, DOI: 10.1017/s1092852926100947.Peer-Reviewed Original ResearchAllostatic load as a mediator of exposomic risk pathways to early-onset cancer: A cross-cohort validation study.
Parikh R, Girard A, Moore T, Visocki E, Bigdeli T, Guloksuz S, McCullough L, Nathanson K, Barzilay R. Allostatic load as a mediator of exposomic risk pathways to early-onset cancer: A cross-cohort validation study. Journal Of Clinical Oncology 2026, 44: 10500-10500. DOI: 10.1200/jco.2026.44.16_suppl.10500.Peer-Reviewed Original ResearchAllostatic loadEarly-onset cancersExposome scoreUK Biobank (UKBUs Research ProgramBurden of chronic stressPopulation-based cohortMediation analysisPrecision prevention approachesPublic health challengeHigh-penetrance mutationsProportional mediationBaseline ALPopulation-level studiesAssociated with ALPsychosocial factorsPolygenic riskSD increaseSocioeconomic indicatorsHealth challengesModifiable targetsUKBBaseline exposureTraditional risk modelsPrevention approachesPsychotropic medication use, lifestyle, genetic risk for high BMI and the incidence of cardiovascular disease
de Boer N, Hanskamp I, Lin B, Boonstra L, van der Horst M, van Eijk K, Boks M, Peyrot W, Twisk J, Goldschmidt T, Pijl H, Vinkers C, Correll C, De Hert M, Guloksuz S, Cahn W, Luykx J. Psychotropic medication use, lifestyle, genetic risk for high BMI and the incidence of cardiovascular disease. Nature Mental Health 2026, 4: 766-774. DOI: 10.1038/s44220-026-00620-w.Peer-Reviewed Original ResearchPsychotropic medication useCardiovascular disease riskUnhealthy lifestyleMedication useHigher BMIPsychotropic usePsychiatric diagnosisCardiovascular diseaseUnhealthy lifestyle behaviorsPositively associated with BMIUK Biobank participantsPsychotropic medication usersHigher CVD riskCardiovascular disease incidenceIncident cardiovascular diseaseUsers of psychotropicsIncidence of cardiovascular diseaseLifestyle behaviorsBiobank participantsHealthy lifestyleMental illnessPolygenic riskCVD riskGenetic riskMedication usersGenetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment “for good and for bad”
Torrecilla P, Lavín V, Arias-Magnasco A, Lin B, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, van Os J, Rutten B, Guloksuz S, Barrantes-Vidal N. Genetic sensitivity to the environment moderates the impact of positive and negative childhood experiences on psychological adjustment “for good and for bad”. European Psychiatry 2026, 69: e41. PMID: 41913453, PMCID: PMC13122527, DOI: 10.1192/j.eurpsy.2026.10176.Peer-Reviewed Original ResearchConceptsGenetic sensitivityDifferential susceptibilityVulnerability-stress frameworkNegative childhood experiencesPositive mental healthPositive experiencesPsychosis expressionSubclinical psychosisEnvironmental exposuresDS effectsPsychological adjustmentChildhood adversityGene-environment interactionsSocial copingChildhood experiencesPolygenic scoresMental healthTwin cohortPositive childhoodDS researchNo significant modelsChildhoodEarly exposureAdversityGxE interactionsSex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study
Doğan M, Prachason T, Fusar-Poli L, Menne-Lothmann C, Decoster J, van Winkel R, Collip D, Delespaul P, De Hert M, Derom C, Thiery E, Jacobs N, Wichers M, Rutten B, van Os J, Pries L, Guloksuz S. Sex differences in the effect of childhood adversity and coping strategies on psychosis expression: A TwinssCan study. European Psychiatry 2026, 69: e42. PMID: 41714187, PMCID: PMC13122524, DOI: 10.1192/j.eurpsy.2026.10173.Peer-Reviewed Original ResearchConceptsChildhood adversityCoping strategiesSocial supportCommunity assessmentPsychosis expressionCommunity Assessment of Psychic ExperiencesCAPE scoresMixed linear regression analysesUtrecht Coping ListEffects of childhood adversityAdaptive coping strategiesSex-specific effectsEmotional neglectPhysical abuseReassuring thoughtsPhysical neglectSex differencesCoping stylesLinear regression analysisGeneral populationCoping mechanismsEmotional abuseAssociation of PESexual abuseChildhood Trauma QuestionnaireSituating problematic gaming and psychotic-like experiences in the adolescent landscape of affordances: A cohort study
Paquin V, Lavallee Z, Huot-Lavoie M, Ku B, Díaz-Caneja C, Gülöksüz S. Situating problematic gaming and psychotic-like experiences in the adolescent landscape of affordances: A cohort study. Journal Of Behavioral Addictions 2026, 15: 320-331. PMID: 41586822, PMCID: PMC13132357, DOI: 10.1556/2006.2025.00094.Peer-Reviewed Original ResearchPsychotic-like experiencesFamily environmentProtect schoolsFamily environment variablesSchool environmentPositive schoolProblematic gamingSchoolDigital gamesLevels of psychotic-like experiencesPeer environmentAdolescent Brain Cognitive Development StudyAssociated with problematic gamingPeerAffordance theoryCognitive Development StudyLandscape of affordancesAssociated with lower levelsAssociated with higher levelsDevelopment studiesAffordabilityEnvironment variablesYouthPartial supportAntipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose
Liu Y, Sommer I, Schoretsanitis G, Hamers I, Scheurink T, Begemann M, Gangadin S, van Beveren N, Consortium H, Sommer I, de Haan L, Veling W, van Os J, Smit F, Begemann M, Koops S, Marcelis M, Kikkert M, van Beveren N, Boonstra N, Rosema B, Bakker P, Gülöksüz S, Lokkerbol J, Wijnen B, Brand B, Gangadin S, van ’t H, Oomen P, Voppel A, de Beer F, Kamphuis S, Hamers I, Djordjevic M, Scheurink T, Noorman J, van Amelsvoort T, Bak M, Berendsen S, van den Brink T, Faber G, Grootens K, de Jonge M, Knegtering H, Kurkamp J, Pijnenborg G, Staring A, Veen N, Veerman S, Wiersma S, Batalla A, Curfs R, Hage J, Graveland E, Hoornaar J, Hobus I, Huizer K, Koops S, Bakker P. Antipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose. European Neuropsychopharmacology 2026, 105: 112769. PMID: 41576855, DOI: 10.1016/j.euroneuro.2026.112769.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisCardiometabolic side effectsFirst-episode psychosis patientsBarnes Akathisia Rating ScaleRating ScaleSt. Hans Rating ScaleMovement disordersTherapeutic drug monitoringAntipsychotic plasma concentrationsStriatal dopamine receptorsPrescription dosePlasma concentrationsSide effectsTardive dyskinesiaDopamine receptorsTardive dystoniaWaist circumferenceCardiometabolic indicesMedian 6-month follow-upLongitudinal associationsLow-density-lipoprotein cholesterolDisordersNon-high-density-lipoprotein cholesterolNon-high-density-lipoproteinBody mass indexSex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study
Prachason T, Arias-Magnasco A, Lin B, van Os J, Rutten B, Pries L, Guloksuz S. Sex differences in the independent and combined effects of genomic and exposomic risks for schizophrenia on distressing psychotic experiences: insights from the ABCD study. Archives Of Women's Mental Health 2026, 29: 7. PMID: 41493491, PMCID: PMC12775040, DOI: 10.1007/s00737-025-01644-4.Peer-Reviewed Original ResearchConceptsDistressing psychotic experiencesPsychotic experiencesPRS-SCZES-SCZEarly adolescenceSex differencesCognitive Development StudySex-dependent effectsJoint associationsAssociated with lifetimeAdolescent brainMultilevel logistic regression modelsABCD studyExposome scorePolygenic riskSchizophreniaSex-stratified analysesConclusionThe influenceSex-dependentLogistic regression modelsAdolescentsFollow-up dataGenomic riskSecondary outcomesPE outcomes
2025
Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions
Schalkwijk W, de Witte L, Gigase F, Cecil C, Suderman M, Gülöksüz S, Rutten B, Boks M. Epigenetic biomarkers of inflammation in studies on mental health: Current applications, limitations, and future directions. Brain Behavior And Immunity 2025, 133: 106245. PMID: 41475675, DOI: 10.1016/j.bbi.2025.106245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEpigenome-wide association studiesMental healthDNA methylationMental illnessDNA methylation markersEpigenetic biomarkersBiomarkers of inflammationC-reactive proteinHealth-related outcomesPhysical health outcomesMental health researchMental Health StudyEWAS studiesLevels of DNA methylationMarkers of inflammationLong-term associationHealth linkHealth outcomesHealth StudyHealth researchComprehensive literature reviewDNA methylation biomarkersHealth risk exposureBlood levelsAssociation studies