Prashanth Vallabhajosyula, MD, MS
ProfessorCards
About
Research
Publications
2026
Contemporary Management of the Aortic Arch: A Narrative Review
Celik N, Ahmad D, Fatimi A, Talapaneni S, Qureshi M, Hameed I, Vallabhajosyula P. Contemporary Management of the Aortic Arch: A Narrative Review. Journal Of Clinical Medicine 2026, 15: 4137. PMID: 42278996, PMCID: PMC13258045, DOI: 10.3390/jcm15114137.Peer-Reviewed Original ResearchFrozen elephant trunkThoracic endovascular aortic repairModified Arch Landing Areas NomenclatureAortic archPatient-specific decision-makingDeep hypothermic circulatory arrestAntegrade cerebral perfusionHypothermic circulatory arrestEndovascular aortic repairConnective tissue diseaseContemporary management strategiesArch replacementSpinal perfusionLifelong surveillanceAortic repairArch operationsEndovascular repairOpen repairCirculatory arrestEndovascular optionsDistal repairFenestrated devicePatient selectionRisk stratificationEarly outcomesClinical, Physiologic, and Anatomic Outcomes of a Novel Bioprosthetic Aortic Valved Conduit
Dankwa S, Erez E, Higaki A, Verma S, Hameed I, Talapaneni S, Wang K, Asmelash S, Oden Shobayo T, Khosla P, Ofori K, Assi R, Vallabhajosyula P. Clinical, Physiologic, and Anatomic Outcomes of a Novel Bioprosthetic Aortic Valved Conduit. Journal Of Clinical Medicine 2026, 15: 3437. PMID: 42123170, PMCID: PMC13163905, DOI: 10.3390/jcm15093437.Peer-Reviewed Original ResearchAortic valved conduitComputed tomographyConclusions:Functional outcomesMethods:Post-operative computed tomographyBio-Bentall procedureAortic root replacementEarly hemodynamic performanceLow mean gradientPost-operative mortalityLate Follow-upNo survival differenceKaplan-Meier analysisEffective orifice areaAnatomical outcomesRoot replacementEchocardiographic parametersPeak gradientComplication rateBetween-group differencesRetrospective studySurvival differencesValved conduitSuperior hemodynamicsCirculating T cell specific extracellular vesicles as biomarkers of acute cellular rejection after lung transplantation
Korutla L, Mineura K, DeMarais N, Liu C, Burke V, Bai Y, Habertheuer A, Hameed I, Terada Y, Talapaneni S, Kawana S, Shepherd H, Ritter J, Kreisel D, Vallabhajosyula P. Circulating T cell specific extracellular vesicles as biomarkers of acute cellular rejection after lung transplantation. American Journal Of Transplantation 2026 PMID: 42061617, DOI: 10.1016/j.ajt.2026.04.021.Peer-Reviewed Original ResearchAcute cellular rejectionLung transplantationT cellsSmall extracellular vesiclesCellular rejectionDense infiltrationCD8+ T cell countsACR diagnosisMouse lung transplant modelNoninvasive method of diagnosisT-cell countsNoninvasive methodTotal T cellsLung transplantation modelClinical lung transplantationExtracellular vesiclesMethods of diagnosisSyngeneic lungAllograft biopsiesLung allograftsTransplantation modelPeripheral circulationTransplantationLungPatientsStrategies for Aortic Root Measurement in Patients Undergoing Surveillance for Thoracic Aortic Disease
Rana A, Hameed I, Dankwa S, Ahmad D, Best C, Asmelash S, Anzueto J, Talapaneni S, Cupo M, Bazarbaev A, Verma S, Lee C, Shobayo T, Vallabhajosyula P. Strategies for Aortic Root Measurement in Patients Undergoing Surveillance for Thoracic Aortic Disease. Journal Of Clinical Medicine 2026, 15: 3349. PMID: 42123083, PMCID: PMC13164044, DOI: 10.3390/jcm15093349.Peer-Reviewed Original ResearchBicuspid aortic valveAortic root diameterAortic rootNon-syndromicMarfan syndromeAortic valveHigh-volume aortic centersAortic root morphologyThoracic aortic diseaseProportion of patientsAortic root measurementsSurgical decision-makingAortic centersSurgical thresholdAortic diseaseCurrent guidelinesSurgical eligibilityComputed tomographyPatientsSpearman rank coefficientFinal analysisMarfanSyndromeRank coefficientSurveillanceUse of Inverse Probability Weighting in Cardiovascular Surgical Outcomes Research: Principles, Limitations, and Recommendations
Liu Z, Ma W, Liu L, Vallabhajosyula P, Wang H. Use of Inverse Probability Weighting in Cardiovascular Surgical Outcomes Research: Principles, Limitations, and Recommendations. European Journal Of Cardio-thoracic Surgery 2026, 68: ezag122. PMID: 41830434, PMCID: PMC13070700, DOI: 10.1093/ejcts/ezag122.Peer-Reviewed Original ResearchInverse probability of treatment weightingOutcomes researchInverse probabilityHeterogeneity of treatment effectsSurgical outcomes researchProbability of treatment weightingConfounding biasCardiovascular Outcomes ResearchResearch principlesConfoundingStatistical primerTreatment weightingAortic arch pathologiesSample sizeTreatment effectsArch pathologiesSurgical approachRetrospective studyBaselineImproper useRecommendationsHealthcare burden of mixed aortic valve stenosis and insufficiency disease
Sultan I, Ryan M, Gunnarsson C, Marfo G, Vallabhajosyula P. Healthcare burden of mixed aortic valve stenosis and insufficiency disease. Journal Of Medical Economics 2026, 29: 761-771. PMID: 41801137, DOI: 10.1080/13696998.2026.2635880.Peer-Reviewed Original ResearchConceptsMixed aortic valve diseaseHealthcare utilizationHealthcare burdenAortic valve replacementHealth care databasesHome health utilizationCare databaseAortic insufficiencyAsymptomatic patientsHealth utilityHigher annual costsCox proportional hazardsAortic stenosisMonths continuous enrollmentBaseline visitGeneralized linear modelHealthcareAortic valve stenosisContinuous enrollmentAortic valve diseaseProportional hazardsUS patientsAnnual costValve replacementEarly detectionManagement of Thoracic Aortic Infections
Hameed I, Vallabhajosyula P. Management of Thoracic Aortic Infections. Contemporary Cardiology 2026, 183-199. DOI: 10.1007/978-3-032-13134-8_13.ChaptersAortic infectionValve endocarditisAortic valve endocarditisProsthetic valve endocarditisAdequate follow-upInfectious aortitisGraft infectionClinical presentationTuberculous aortitisSurgical managementSurgical optionsClinical entityClinical findingsCase reportGood outcomeLaboratory valuesFollow-upOriginal graftSyphilitic aortitisTissue graftAortitisAbnormal inflammationAppropriate guidelinesAortic wallExtensive literature searchPregnancy-associated vascular complications and thoracic aortic growth patterns
Nasir A, Waldron C, Vallabhajosyula P, Murugiah K, Assi R. Pregnancy-associated vascular complications and thoracic aortic growth patterns. JTCVS Structural And Endovascular 2026, 10: 100104. PMID: 42306275, PMCID: PMC13244768, DOI: 10.1016/j.xjse.2026.100104.Peer-Reviewed Original ResearchThoracic aortic diseaseThoracic aortic aneurysmElectronic health recordsAortic diseaseVascular complicationsAortic aneurysmDiagnosis of thoracic aortic aneurysmClinical managementPregnancy-related vascular complicationsRecords of pregnant patientsHeritable thoracic aortic diseaseClinical management of pregnancyManagement of pregnancyConnective tissue diseaseAcute aortic eventsAortic surveillanceObjective PregnancyObstetric populationPregnant patientsAortic eventsAortic sizeArterial complicationsAortic dissectionTissue diseaseThoracic aortaLeveraging in-silico deep learning and computational analyses to predict the pathogenicity of ROBO4 variants of uncertain significance in aortic aneurysm and dissection patients
Lee C, Hameed I, Cupo M, Erez E, Ahmad H, Lee J, Verma S, Saeed W, Fatimi A, Assi R, Vallabhajosyula P. Leveraging in-silico deep learning and computational analyses to predict the pathogenicity of ROBO4 variants of uncertain significance in aortic aneurysm and dissection patients. BMC Cardiovascular Disorders 2026, 26: 173. PMID: 41639767, PMCID: PMC12922274, DOI: 10.1186/s12872-025-05357-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic Aneurysm, ThoracicAortic DissectionComputational BiologyDeep LearningFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutation, MissensePatient-Specific ModelingPedigreePhenotypePredictive Value of TestsReceptors, Cell SurfaceRoundabout ProteinsStructure-Activity RelationshipConceptsPathogenic potentialSignificance of genetic variantsThoracic aortic aneurysmBeta-sheet structureMissense VUSsGenotype-phenotype correlationPolyPhen-2Aortic aneurysmPathogenicity predictionPathogenic significanceGenetic dataResidue positionsGenetic variantsBiochemical propertiesROBO4 genesVUSClinical dataPathogensExtracellular domain variantsDomain variantsComputational predictionsAscending Aortic AneurysmGenesPrecision medicineVariants
2025
Prosthesis–Patient Mismatch Following Aortic Valve Replacement—A Comprehensive Review
Talapaneni S, Ahmad D, Khandelwal M, Mesiha M, Jalali P, Celik N, Tabraiz S, Dankwa S, Hameed I, Milewski R, Vallabhajosyula P. Prosthesis–Patient Mismatch Following Aortic Valve Replacement—A Comprehensive Review. Journal Of Clinical Medicine 2025, 14: 8868. PMID: 41464770, PMCID: PMC12733721, DOI: 10.3390/jcm14248868.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProsthesis-patient mismatchAortic valve replacementPatient's body surface areaBioprosthetic valve fractureValve replacementTransvalvular gradientSurgical valvesLeft ventricular mass regressionAccurate preoperative imagingRates of heart failureCoronary flow abnormalitiesLong-term outcomesBody surface areaValve-in-valveEffective orifice areaIndividual patient anatomyNarrative reviewAnnular enlargementPreoperative imagingLate mortalityPatient survivalClinical outcomesCardiac remodelingMass regressionCoronary access
Clinical Trials
Current Trials
CorMatrix Cor TRICUSPID ECM Valve Replacement Study
IRB ID2000028726RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge1 year - 70 years
Clinical Care
Overview
Prashanth Vallabhajosyula, MD, MS, is surgical director of the Aortic Institute, which is part of the Yale New Haven Health Heart & Vascular Center. He is a cardiothoracic surgeon who performs the entire spectrum of heart surgeries, including coronary artery bypass grafting, valve surgery, and heart transplantation. His primary focus is endovascular and open surgeries of the aorta, and hybrid surgeries that combine the two.
Dr. Vallabhajosyula is skilled in complex procedures, such as thoracic endovascular aortic repair (TEVAR), a minimally invasive procedure that uses a stent graft to reinforce an aneurysm and prevent it from bursting. He also introduced pulmonary thromboendarterectomy to Yale. The latter is a highly specialized surgical procedure that removes chronic blood clots from the arteries in the lung.
As director of the Aortic Institute, Dr. Vallabhajosyula says a large part of his work is coordinating and integrating a variety of services. “A multidisciplinary approach is important, because what we can offer patients for a particular aortic disease is rapidly evolving,” Dr. Vallabhajosyula says, explaining this that can change how different specialists can contribute to a case. “People draw arbitrary lines around what vascular surgery will do, what cardiology will do, and what a heart surgeon will do, but patients don't always understand that or come in that way. Our goal is to integrate all the services and provide a single place for patients to come if they have an aortic problem.”
Dr. Vallabhajosyula says one thing that led him to medicine was a lifelong love of science. “When I was in sixth grade, growing up in India, my mother took me to a medical university for a show they had where kids from elementary school could see human bones,” he says. “There was an anatomy lab going on, and I snuck into it and saw some cadavers. I wasn’t scared at all. I was fascinated by the human body and with seeing all these parts, and truly understanding that there is such an organic basis to everything that we do. I was hooked from the very beginning.”
He also enjoyed any experience that involved helping people, which led to his decision to be a surgeon. “Patient care is a phenomenal thing,” he says. While patients and their families are grateful for what he can do for them, he also gets a lot back, he adds. “I really try to understand patients for who they are and where they are coming from. If you approach patient care that way, you come to realize that we're all pretty similar. I think that’s made me a better person,” he says.
Clinical Specialties
Fact Sheets
Aortic Aneurysm
Learn More on Yale MedicineEndovascular Debranching Aortic Repair for Thoracoabdominal Aortic Aneurysms
Learn More on Yale MedicinePulmonary Thromboendarterectomy
Learn More on Yale MedicineReoperative Heart Surgery
Learn More on Yale Medicine
Board Certifications
Thoracic & Cardiac Surgery
- Certification Organization
- AB of Thoracic Surgery
- Original Certification Date
- 2012
Yale Medicine News
News
News
- May 19, 2026
Novel Blood Test Detects Rejection After Lung Transplant
- June 26, 2025
For Heart Transplant Patients, Blood Test May Detect Rejection Earlier and More Easily
- March 11, 2025Source: New Haven Register
How Yale doctors used a balloon in surgery to treat heart issue
- January 14, 2025
Yale Team Performs State’s First BATMAN Procedure
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Cardiac Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
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Everyone Prashanth Vallabhajosyula, MD, MS - David P. Kuwayama, MD, MPA, MPhil - John Elefteriades, MD - Sandip Mukherjee, MD, FACC