Matthew McConnell, MD
Assistant Professor of Medicine (Digestive Diseases)DownloadHi-Res Photo
Cards
Appointments
Digestive Diseases
Primary
Additional Titles
Associate Program Director, Gastroenterology Fellowship, Digestive Diseases
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Digestive Diseases
Primary
Additional Titles
Associate Program Director, Gastroenterology Fellowship, Digestive Diseases
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
Appointments
Digestive Diseases
Primary
Additional Titles
Associate Program Director, Gastroenterology Fellowship, Digestive Diseases
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
About
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Titles
Assistant Professor of Medicine (Digestive Diseases)
Associate Program Director, Gastroenterology Fellowship, Digestive Diseases
Appointments
Digestive Diseases
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- MD
- Weill Cornell Medical College (2012)
- BA
- Amherst College, Chemistry (2006)
Research
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Overview
Medical Research Interests
Blood Platelets; Liver Diseases; Liver Diseases, Alcoholic
ORCID
0000-0002-8522-0381
Research at a Glance
Yale Co-Authors
Frequent collaborators of Matthew McConnell's published research.
Publications Timeline
A big-picture view of Matthew McConnell's research output by year.
Research Interests
Research topics Matthew McConnell is interested in exploring.
Yasuko Iwakiri, PhD
Jain Jeong, PhD
Xuchen Zhang, MD, PhD
Yilin Yang
John Hwa, MD, PhD, FRACP
Mario Strazzabosco, MD, PhD, MSc
21Publications
923Citations
Liver Diseases
Blood Platelets
Liver Diseases, Alcoholic
Publications
2026
Applying flow cytometry-based isolation of platelet-derived microparticles to banked human plasma for cellular studies.
Fattahi N, Tyagi T, Kirlin F, Flores AL, Hwa J, Iwakiri Y, McConnell MJ. Applying flow cytometry-based isolation of platelet-derived microparticles to banked human plasma for cellular studies. J Pathol 2026 PMID: 42446223, DOI: 10.1002/path.70097.Peer-Reviewed Original ResearchHepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages
Ma R, Gong L, Dong C, Utsumi T, Qi J, Zhuang Z, Zhang X, Yang Y, McConnell M, Huang H, Iwakiri Y. Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing Macrophages. Cellular And Molecular Gastroenterology And Hepatology 2026, 20: 101728. PMID: 41565157, PMCID: PMC13090736, DOI: 10.1016/j.jcmgh.2026.101728.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original ResearchCitationsAltmetric
2023
The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis
Tanaka M, Jeong J, Thomas C, Zhang X, Zhang P, Saruwatari J, Kondo R, McConnell M, Utsumi T, Iwakiri Y. The Sympathetic Nervous System Promotes Hepatic Lymphangiogenesis, which Is Protective Against Liver Fibrosis. American Journal Of Pathology 2023, 193: 2182-2202. PMID: 37673329, PMCID: PMC10699132, DOI: 10.1016/j.ajpath.2023.08.004.Peer-Reviewed Original ResearchCitationsAltmetricAn optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver
Jeong J, Tanaka M, Yang Y, Arefyev N, DiRito J, Tietjen G, Zhang X, McConnell M, Utsumi T, Iwakiri Y. An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver. AJP Gastrointestinal And Liver Physiology 2023, 325: g379-g390. PMID: 37605828, PMCID: PMC10887843, DOI: 10.1152/ajpgi.00139.2023.Peer-Reviewed Original ResearchCitationsAltmetricPortal Hypertension in Alcohol-Associated Hepatitis
McConnell M, Iwakiri Y. Portal Hypertension in Alcohol-Associated Hepatitis. Current Hepatology Reports 2023, 22: 67-73. PMID: 37214274, PMCID: PMC10075503, DOI: 10.1007/s11901-023-00601-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsThe evolving role of liver sinusoidal endothelial cells in liver health and disease
McConnell M, Kostallari E, Ibrahim S, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology 2023, 78: 649-669. PMID: 36626620, PMCID: PMC10315420, DOI: 10.1097/hep.0000000000000207.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2021
Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases
Kondo R, Kawaguchi N, McConnell MJ, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Sun Z, Utsumi T, Strazzabosco M, Iwakiri Y. Pathological characteristics of liver sinusoidal thrombosis in COVID‐19 patients: A series of 43 cases. Hepatology Research 2021, 51: 1000-1006. PMID: 34260803, PMCID: PMC8444906, DOI: 10.1111/hepr.13696.Peer-Reviewed Original ResearchCitationsAltmetricLiver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy
McConnell MJ, Kawaguchi N, Kondo R, Sonzogni A, Licini L, Valle C, Bonaffini PA, Sironi S, Alessio MG, Previtali G, Seghezzi M, Zhang X, Lee A, Pine AB, Chun HJ, Zhang X, Fernandez-Hernando C, Qing H, Wang A, Price C, Sun Z, Utsumi T, Hwa J, Strazzabosco M, Iwakiri Y. Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy. Journal Of Hepatology 2021, 75: 647-658. PMID: 33991637, PMCID: PMC8285256, DOI: 10.1016/j.jhep.2021.04.050.Peer-Reviewed Original ResearchCitationsAltmetricAlcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease
Yang Y, Sangwung P, Kondo R, Jung Y, McConnell MJ, Jeong J, Utsumi T, Sessa WC, Iwakiri Y. Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcohol-related liver disease. Journal Of Hepatology 2021, 75: 377-386. PMID: 33675874, PMCID: PMC8292196, DOI: 10.1016/j.jhep.2021.02.028.Peer-Reviewed Original ResearchCitationsAltmetric
Academic Achievements & Community Involvement
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Honors
honor Samuel Kushlan Junior Faculty Award for Excellence in Clinical Research
06/23/2020Yale School of Medicine AwardDetailsUnited Stateshonor Samuel Kushlan Award for Excellence in Research during Digestive Diseases Fellowship
06/19/2018Yale School of Medicine AwardDetailsUnited States
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Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States