Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsIkki Sakuma
Assistant Professor AdjunctAbout
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Assistant Professor Adjunct
Appointments
Endocrinology
Assistant Professor AdjunctPrimary
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Research
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Ikki Sakuma's published research.
Publications Timeline
A big-picture view of Ikki Sakuma's research output by year.
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
Rafael Calais Gaspar, PhD, MSc
Kitt Petersen, MD
Mario Kahn
Varman Samuel, MD, PhD
Daniel F Vatner, MD, PhD
17Publications
141Citations
Publications
2026
Baxdrostat versus Osilodrostat: Steroid Biosynthesis in Human Adrenocortical Cells.
Taki Y, Kono T, Sakuma I, Hashimoto N, Yokoyama M, Kawakami E, Miki T, Sasano H, Nakamura Y, Tanaka T. Baxdrostat versus Osilodrostat: Steroid Biosynthesis in Human Adrenocortical Cells. Endocrine Connections 2026 PMID: 42307048, DOI: 10.1530/ec-25-0807.Peer-Reviewed Original ResearchCIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity
Sakuma I, Gaspar R, Morgan H, Zheng J, Nasiri A, Dufour S, Kahn M, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Samuel V, Tanaka T, Shulman G. CIDEB and CGI-58 differentially regulate liver lipid-droplet cholesterol to modulate metabolic dysfunction-associated steatohepatitis severity. Cell Reports 2026, 45: 117369. PMID: 42234563, DOI: 10.1016/j.celrep.2026.117369.Peer-Reviewed Original ResearchCitationsAltmetricWestern diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction
Rodríguez-López S, Pérez-Rodríguez M, Badreddine A, Gaspar R, Novaes Morgan H, Sakuma I, von Alvensleben G, Alonso-Calleja A, Everts S, Suter N, Benegiamo G, Goepfert C, de Brot S, Villalba J, Shulman G, Schoonjans K, Auwerx J. Western diet-induced MASH in PWK/PhJ mice identifies disruptions in amino acid and sphingolipid metabolism contributing to cardiac dysfunction. Nature Communications 2026 PMID: 42156763, DOI: 10.1038/s41467-026-73449-7.Peer-Reviewed Original ResearchAltmetricLSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC
Machida T, Gong Y, Tsukioka S, Onodera A, Nakayama A, Hashimoto N, Fuchigami T, Nishimura M, Ogino T, Kurimoto R, Uematsu Y, Suzuki H, Yu H, Chen M, Yokoyama M, Sakuma I, Taki Y, Kono T, Miki T, Motohashi S, Kawashima Y, Ohara O, Yamashita S, Suzuki T, Hatanaka R, Kodama Y, Ohkubo S, Tanaka T. LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC. Nature Communications 2026, 17: 4390. PMID: 41881985, PMCID: PMC13181136, DOI: 10.1038/s41467-026-70984-1.Peer-Reviewed Original ResearchAltmetricAxis-Specific Peripartum Management for Radiation-Induced Panhypopituitarism With Arginine Vasopressin Deficiency: A Case Report
Kono T, Miyagawa H, Kawauchi Y, Taki Y, Sakuma I, Hashimoto N, Oki Y, Shimatsu A, Tanaka T. Axis-Specific Peripartum Management for Radiation-Induced Panhypopituitarism With Arginine Vasopressin Deficiency: A Case Report. AACE Endocrinology And Diabetes 2026, 13: 512-517. PMID: 42221410, PMCID: PMC13221946, DOI: 10.1016/j.aed.2026.01.006.Peer-Reviewed Original Research
2025
Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway
Zheng J, Gaspar R, Sakuma I, Hubbard B, Zhang D, Nasiri A, Kahn M, Perelis M, Samuel V, Petersen K, Shulman G. Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway. Diabetologia 2025, 68: 2906-2920. PMID: 40908405, DOI: 10.1007/s00125-025-06539-8.Peer-Reviewed Original ResearchCitationsAltmetricp53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance
Tamura A, Yamagata K, Kono T, Fujimoto M, Fuchigami T, Nishimura M, Yokoyama M, Nakayama A, Hashimoto N, Sakuma I, Mitsukawa N, Kawashima Y, Ohara O, Motohashi S, Kawakami E, Miki T, Onodera A, Tanaka T. p53-inducible lncRNA LOC644656 causes genotoxic stress-induced stem cell maldifferentiation and cancer chemoresistance. Nature Communications 2025, 16: 4818. PMID: 40410129, PMCID: PMC12102190, DOI: 10.1038/s41467-025-59886-w.Peer-Reviewed Original ResearchCitationsAltmetricLiver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis
Sakuma I, Gaspar R, Nasiri A, Dufour S, Kahn M, Zheng J, LaMoia T, Guerra M, Taki Y, Kawashima Y, Yimlamai D, Perelis M, Vatner D, Petersen K, Huttasch M, Knebel B, Kahl S, Roden M, Samuel V, Tanaka T, Shulman G. Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction–associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2502978122. PMID: 40310463, PMCID: PMC12067271, DOI: 10.1073/pnas.2502978122.Peer-Reviewed Original ResearchCitationsAltmetricProtocol for characterizing craniopharyngioma subtypes and their microenvironments using single-cell RNA sequencing and immunohistochemistry
Kono T, Matsuda T, Fujimoto M, Taki Y, Sakuma I, Hashimoto N, Nakamura Y, Horiguchi K, Higuchi Y, Onodera A, Miki T, Tanaka T. Protocol for characterizing craniopharyngioma subtypes and their microenvironments using single-cell RNA sequencing and immunohistochemistry. STAR Protocols 2025, 6: 103760. PMID: 40238632, PMCID: PMC12022695, DOI: 10.1016/j.xpro.2025.103760.Peer-Reviewed Original ResearchAltmetricShort- and long-term glycemic effects of pasireotide in patients with acromegaly: a comprehensive case study with review of literature
Taki Y, Kono T, Matsuda T, Kozu R, Fujimoto M, Sakuma I, Hashimoto N, Horiguchi K, Higuchi Y, Tanaka T. Short- and long-term glycemic effects of pasireotide in patients with acromegaly: a comprehensive case study with review of literature. Endocrine Journal 2025, 72: 421-435. PMID: 39842795, PMCID: PMC11997266, DOI: 10.1507/endocrj.ej24-0548.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
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