Christopher A Baker, PhD
Associate Research ScientistCards
About
Research
Publications
Featured Publications
Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin.
Baker CA, Elyada YM, Parra A, Bolton MM. Cellular resolution circuit mapping with temporal-focused excitation of soma-targeted channelrhodopsin. ELife 2016, 5 PMID: 27525487, PMCID: PMC5001837, DOI: 10.7554/eLife.14193.Peer-Reviewed Original ResearchSynaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation.
Hage TA, Bosma-Moody A, Baker CA, Kratz MB, Campagnola L, Jarsky T, Zeng H, Murphy GJ. Synaptic connectivity to L2/3 of primary visual cortex measured by two-photon optogenetic stimulation. Elife 2022, 11 PMID: 35060903, DOI: 10.7554/eLife.71103.Peer-Reviewed Original ResearchUnique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease
Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 675-679. PMID: 12525699, PMCID: PMC141055, DOI: 10.1073/pnas.0237313100.Peer-Reviewed Original ResearchConceptsCreutzfeldt-Jakob diseaseMyeloid cellsUninfected microgliaInflammatory pathwaysMicroglial cellsIFN-gammaInflammatory stimuliMicrogliaInflammatory genesProtein pathologyInfectious agentsPreclinical diagnosisNeurodegenerative diseasesTransmissible spongiformDiseaseBrainPrP amyloidRNA profilesExpression profilesCellsCDNA arraysPrevious studiesInfectionDiagnosisPathology
2026
Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes.
Bhagchandani SH, Ehrenzeller S, Pires IS, Chaudhary N, Booth CJ, Kwon DI, Koutsioumpa C, Baker CA, Laxton C, Santos Guedes de Sá K, Matthews C, Gill P, Li S, Olszowka A, Hudak A, Fischer S, Bayarri-Olmos R, Hooper WB, Iwasaki A. Bioactive enhanced adjuvant chemokine oligonucleotide nanoparticles (BEACONs) for mucosal vaccination against genital herpes. Sci Immunol 2026, 11: eaea6419. PMID: 42319912, DOI: 10.1126/sciimmunol.aea6419.Peer-Reviewed Original ResearchThis study investigates a novel vaccine strategy using BEACONs, a mucosal adjuvant, to enhance localized immunity and protect against genital herpes by boosting tissue-resident T cells and antibodies.
2024
Spying on specific splicing in spinal nerve injury.
Baker CA. Spying on specific splicing in spinal nerve injury. Neurotherapeutics 2024, 21: e00315. PMID: 38216398, DOI: 10.1016/j.neurot.2024.e00315.Commentaries, Editorials and Letters
2023
Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator.
Abdelfattah AS, Zheng J, Singh A, Huang YC, Reep D, Tsegaye G, Tsang A, Arthur BJ, Rehorova M, Olson CVL, Shuai Y, Zhang L, Fu TM, Milkie DE, Moya MV, Weber TD, Lemire AL, Baker CA, Falco N, Zheng Q, Grimm JB, Yip MC, Walpita D, Chase M, Campagnola L, Murphy GJ, Wong AM, Forest CR, Mertz J, Economo MN, Turner GC, Koyama M, Lin BJ, Betzig E, Novak O, Lavis LD, Svoboda K, Korff W, Chen TW, Schreiter ER, Hasseman JP, Kolb I. Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator. Neuron 2023, 111: 1547-1563.e9. PMID: 37015225, DOI: 10.1016/j.neuron.2023.03.009.Peer-Reviewed Original Research
2021
Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.
Bonnan A, Rowan MMJ, Baker CA, Bolton MM, Christie JM. Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling. Nature Communications 2021, 12: 2153. PMID: 33846328, PMCID: PMC8042043, DOI: 10.1038/s41467-021-22405-8.Peer-Reviewed Original Research
2019
Regional Specialization of Pyramidal Neuron Morphology and Physiology in the Tree Shrew Neocortex.
Parra A, Baker CA, Bolton MM. Regional Specialization of Pyramidal Neuron Morphology and Physiology in the Tree Shrew Neocortex. Cerebral Cortex (New York, N.Y. : 1991) 2019, 29: 4488-4505. PMID: 30715235, DOI: 10.1093/cercor/bhy326.Peer-Reviewed Original Research
2018
A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality.
Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H. A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality. Cell 2018, 174: 465-480.e22. PMID: 30007418, PMCID: PMC6086366, DOI: 10.1016/j.cell.2018.06.035.Peer-Reviewed Original ResearchTwo-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo.
Forli A, Vecchia D, Binini N, Succol F, Bovetti S, Moretti C, Nespoli F, Mahn M, Baker CA, Bolton MM, Yizhar O, Fellin T. Two-Photon Bidirectional Control and Imaging of Neuronal Excitability with High Spatial Resolution In Vivo. Cell Reports 2018, 22: 3087-3098. PMID: 29539433, PMCID: PMC5863087, DOI: 10.1016/j.celrep.2018.02.063.Peer-Reviewed Original Research
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