Bryan D. Mckiver, MS, PhD
he/him/his
Postdoctoral FellowAbout
Research
Publications
2026
A critical role for α7 nicotinic acetylcholine receptor signaling in myeloid lineage cells in chronic neuropathic and inflammatory pain responses
Swift A, Caillaud M, Graur A, McKiver B, Toma W, Koseli E, Mann J, Lynch W, Beierle J, Thareja P, Yao E, Windle J, Beauzile H, Oh U, Thakur G, Burton M, Bryant C, Kabbani N, Damaj M. A critical role for α7 nicotinic acetylcholine receptor signaling in myeloid lineage cells in chronic neuropathic and inflammatory pain responses. Journal Of Pain 2026, 46: 106339. PMID: 42229868, DOI: 10.1016/j.jpain.2026.106339.Peer-Reviewed Original ResearchAromatase inhibitors induce pain‐like musculoskeletal symptoms in mice: behavioural, pharmacological and pathophysiological characterization
Caillaud M, Herz S, Koseli E, Roberts J, Ulker E, Jessup D, McKiver B, Silva G, Betancourt‐Toscano I, Diaz N, Khan A, Poklis J, Henry N, Akbarali H, Damaj M. Aromatase inhibitors induce pain‐like musculoskeletal symptoms in mice: behavioural, pharmacological and pathophysiological characterization. British Journal Of Pharmacology 2026, 183: 2287-2306. PMID: 41482508, PMCID: PMC13001628, DOI: 10.1111/bph.70313.Peer-Reviewed Original Research
2025
Paclitaxel-induced neuroinflammation after systemic administration in male and female mice
Caillaud M, Rakholia Y, Soleo L, Mckiver B, Toma W, Burton M, Wages N, Das P, Damaj M. Paclitaxel-induced neuroinflammation after systemic administration in male and female mice. Journal Of Pain 2025, 35: 105510. PMID: 40721131, PMCID: PMC12364537, DOI: 10.1016/j.jpain.2025.105510.Peer-Reviewed Original ResearchAstrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy
Mckiver B, Herz S, Patel S, Bryan T, Mann J, Poklis J, Bigbee J, Windle J, Salem A, Sarkar D, Damaj M. Astrocyte elevated gene-1 (AEG-1) in myeloid cells is a key driver for the development of chemotherapy-induced peripheral neuropathy. Brain Behavior And Immunity 2025, 127: 329-340. PMID: 40101807, DOI: 10.1016/j.bbi.2025.03.020.Peer-Reviewed Original ResearchBehavioral and transcriptional effects of age in HbSS-BERK humanized SCD mice
Goldsborough K, Taylor M, McKiver B, Muchhala K, Sonenklar M, Adu-Gyamfi A, Herz S, Jessup D, Lloyd J, Akbarali H, Damaj M, Gupta K, Smith W, Lichtman A. Behavioral and transcriptional effects of age in HbSS-BERK humanized SCD mice. Journal Of Sickle Cell Disease 2025, 2: yoaf033. PMID: 41244884, PMCID: PMC12619645, DOI: 10.1093/jscdis/yoaf033.Peer-Reviewed Original Research
2024
Proteomic analysis of dorsal root ganglia in a mouse model of paclitaxel-induced neuropathic pain
Hanna R, Graur A, Sinclair P, Mckiver B, Bos P, Damaj M, Kabbani N. Proteomic analysis of dorsal root ganglia in a mouse model of paclitaxel-induced neuropathic pain. PLOS ONE 2024, 19: e0306498. PMID: 39331687, PMCID: PMC11432834, DOI: 10.1371/journal.pone.0306498.Peer-Reviewed Original Research
2023
A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain
Gomez K, Santiago U, Nelson T, Allen H, Calderon-Rivera A, Hestehave S, Palma E, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang K, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora P, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj M, Korczeniewska O, Camacho C, Khanna R. A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305215120. PMID: 37972067, PMCID: PMC10666126, DOI: 10.1073/pnas.2305215120.Peer-Reviewed Original ResearchConceptschronic paincalcium channelspain reliefcalcium influxdepolarization-evoked calcium influxrat dorsal root ganglion neuronsdorsal root ganglion neuronsvoltage-gated calcium channelsN-type calcium channelsside effect profilefirst-in-classpeptidomimetic small moleculenegative side effect profilesinflammatory painresponse to mechanical stimulationsensory neuron membranecollapsin response mediator protein 2pain targetsabuse liabilitycalcium responseeffect profileganglion neuronspaintransmitter releaseside effectsVitamin D insufficiency as a risk factor for paclitaxel-induced peripheral neuropathy in SWOG S0221
Chen C, Zirpoli G, Barlow W, Budd G, McKiver B, Pusztai L, Hortobagyi G, Albain K, Damaj M, Godwin A, Thompson A, Henry N, Ambrosone C, Stringer K, Hertz D. Vitamin D insufficiency as a risk factor for paclitaxel-induced peripheral neuropathy in SWOG S0221. Journal Of The National Comprehensive Cancer Network 2023, 21: 1172-1180.e3. PMID: 37935109, PMCID: PMC10976748, DOI: 10.6004/jnccn.2023.7062.Peer-Reviewed Original ResearchConceptschemotherapy-induced peripheral neuropathyvitamin D insufficiencyD insufficiencyvitamin Dpaclitaxel schedulemechanical hypersensitivityperipheral neuropathyrisk factorsdeficient dietpaclitaxel-induced peripheral neuropathyearly-stage breast cancerpaclitaxel-containing chemotherapyvitamin D supplementationsufficient vitamin Dvitamin D deficiencybody mass indexmultiple logistic regressionself-reported raceD supplementationD deficiencysensitized miceprospective trialfemale patientsmass indexpredictive biomarkersIdentification and targeting of a unique NaV1.7 domain driving chronic pain
Gomez K, Stratton H, Duran P, Loya S, Tang C, Calderon-Rivera A, François-Moutal L, Khanna M, Madura C, Luo S, McKiver B, Choi E, Ran D, Boinon L, Perez-Miller S, Damaj M, Moutal A, Khanna R. Identification and targeting of a unique NaV1.7 domain driving chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2217800120. PMID: 37498871, PMCID: PMC10410761, DOI: 10.1073/pnas.2217800120.Peer-Reviewed Original Research
2022
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Toma W, Paris J, Warncke U, Nass S, Caillaud M, McKiver B, Ondo O, Bagdas D, Bigbee J, Knapp P, Hauser K, Damaj M. Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. Experimental Neurology 2022, 358: 114226. PMID: 36096180, PMCID: PMC10053560, DOI: 10.1016/j.expneurol.2022.114226.Peer-Reviewed Original ResearchConceptssensory neuropathyfemale miceHIV-1Tat expressionsensory nerve action potentialsintraepidermal nerve fiber densitychronic HIV-1persistent sensory changespain-like behaviorsperipheral sensory neuropathysevere chronic paindevelopment of neuropathynerve fiber densitylumbar spinal corddevelopment of hypersensitivitynerve action potentialsprevious preclinical studiesdorsal root gangliaTNF-α expressionPPAR-α gene expressionTat regulatory proteinrole of TatHIV-1 Tatsex differencesallodynic responses