Brian Tanaka, PhD
Associate Research ScientistDownloadHi-Res Photo
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Center for Neuroscience and Regeneration Research
950 Campbell Ave., Bldg 34
West Haven, CT 06516
United States
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Associate Research Scientist
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Education & Training
- PhD
- University of California, Irvine (2013)
Research
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Overview
Medical Research Interests
Electrophysiology; Ion Channels; Neurosciences; Pain
Research at a Glance
Yale Co-Authors
Frequent collaborators of Brian Tanaka's published research.
Research Interests
Research topics Brian Tanaka is interested in exploring.
Mark Estacion, PhD
Sulayman Dib-Hajj, PhD
Publications
2020
Pharmacological activity and NMR solution structure of the leech peptide HSTX-I
McMahon KL, Tay B, Deuis JR, Tanaka BS, Peigneur S, Jin AH, Tytgat J, Waxman SG, Dib-Hajj SD, Vetter I, Schroeder CI. Pharmacological activity and NMR solution structure of the leech peptide HSTX-I. Biochemical Pharmacology 2020, 181: 114082. PMID: 32524995, PMCID: PMC8494138, DOI: 10.1016/j.bcp.2020.114082.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNMR solution spectroscopyOne-pot oxidationSolution structureLow micromolar activitySolution spectroscopyThree-dimensional solution structureSingle-step purificationMicromolar activityNMR solution structureHydrophobic peptidesIon channel subtypesHigh yieldsPeptide toxinsStep purificationPharmacological activitiesDisulfide bondsTetrodotoxin-resistant isoformsTetrodotoxin-resistant NaPathogenesis of painVoltage-gated sodium channelsNaSubAnalgesic efficacyInflammatory painSpectroscopyDifferential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy
Labau J, Estacion M, Tanaka BS, de Greef B, Hoeijmakers J, Geerts M, Gerrits MM, Smeets H, Faber CG, Merkies I, Lauria G, Dib-Hajj SD, Waxman SG. Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. Brain 2020, 143: 771-782. PMID: 32011655, PMCID: PMC7089662, DOI: 10.1093/brain/awaa016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmall fiber neuropathyEffects of lacosamideNon-responsive patientsSubset of patientsCommon pain disordersRecent clinical studiesUse-dependent inhibitionUse-dependent mannerVoltage-clamp recordingsPotent sodium channel inhibitorSlow inactivationSodium channel inhibitorsNeuronal hyperexcitabilityResponsive patientsPain disordersNav1.7 mutationClinical studiesAchievable concentrationsPatientsLacosamideNeuropathyChannel inhibitorsSodium channelsPainFunction mutations
2019
NaV1.6 regulates excitability of mechanosensitive sensory neurons
Israel MR, Tanaka BS, Castro J, Thongyoo P, Robinson SD, Zhao P, Deuis JR, Craik DJ, Durek T, Brierley SM, Waxman SG, Dib‐Hajj S, Vetter I. NaV1.6 regulates excitability of mechanosensitive sensory neurons. The Journal Of Physiology 2019, 597: 3751-3768. PMID: 31087362, DOI: 10.1113/jp278148.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeripheral sensory neuronsPeripheral nervous systemDorsal root ganglion neuronsSensory neuronsVoltage-gated sodium channelsGanglion neuronsSodium channelsLarge-diameter dorsal root ganglion neuronsTonic action potential firingWhole-cell patch-clamp recordingsMultiple voltage-gated sodium channelsIntra-plantar injectionMechanosensitive sensory neuronsVivo behavioral assessmentsAction potential firingChannel activationPatch-clamp recordingsPotential therapeutic targetMechanical stimuliΒ-scorpion toxinSodium channel isoformsPain pathwaysThermal allodyniaPain generationSensory afferents
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Center for Neuroscience and Regeneration Research
950 Campbell Ave., Bldg 34
West Haven, CT 06516
United States