Lin Lin
Postdoctoral AssociateAbout
Research
Publications
2025
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Lin Y, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 643: 744-754. PMID: 40533550, PMCID: PMC12267058, DOI: 10.1038/s41586-025-09083-y.Peer-Reviewed Original ResearchPost-traumatic stress disorderPrefrontal cortexDorsolateral prefrontal cortexHuman prefrontal cortexTraumatic stress responseHuman brainDepressive disorderStress disorderTrauma exposureCell type-specific contextRegulatory mechanismsGABAergic transmissionCell-type clusteringCell type-specific mannerMolecular regulatory mechanismsGlucocorticoid signalingGene expression changesChromatin dynamicsCredible variantsDisordersTranscriptional regulationEpigenetic dataCortexPersistent effectsPolygenic disorderTranslaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex
Vargas-Ortiz J, Lin L, Martinez V, Liu R, Babij R, Duan Z, Wacks S, Sun L, Wang A, Khan S, Soto-Vargas J, De Marco García N, Che A. Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex. Nature Communications 2025, 16: 1296. PMID: 39900899, PMCID: PMC11791040, DOI: 10.1038/s41467-024-55783-w.Peer-Reviewed Original ResearchThis study shows how connections across layers in the cortex synchronize early brain activity, guiding sensory development and informing strategies to address neurodevelopmental disorders.
2023
Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus
Ma Y, Shu W, Lin L, Cao X, Oertel D, Smith P, Jackson M. Imaging Voltage Globally and in Isofrequency Lamina in Slices of Mouse Ventral Cochlear Nucleus. ENeuro 2023, 10: eneuro.0465-22.2023. PMID: 36792362, PMCID: PMC9997695, DOI: 10.1523/eneuro.0465-22.2023.Peer-Reviewed Original ResearchConceptsHybrid voltage sensorCochlear nucleusPopulations of neuronsIsofrequency laminaMouse ventral cochlear nucleusVoltage-sensitive dye signalsVentral cochlear nucleusTargeting of neuronsReceptor-independent signalingNerve fiber stimulationVoltage-sensitive dyeHigher processing centersFiber stimulationPostsynaptic responsesCre recombinaseVoltage imagingUnmyelinated axonsNeuronsAuditory systemAxonal originCN slicesDye signalsProbe expressionSensory processingImaging voltage
2022
Local targets of T‐stellate cells in the ventral cochlear nucleus
Lin L, Campbell J, Oertel D, Smith P. Local targets of T‐stellate cells in the ventral cochlear nucleus. The Journal Of Comparative Neurology 2022, 530: 2820-2834. PMID: 35716380, PMCID: PMC9474575, DOI: 10.1002/cne.25378.Peer-Reviewed Original ResearchConceptsT stellate cellsVentral cochlear nucleusT-stellateIsofrequency laminaCochlear nucleusInferior colliculusAdeno-associated viral vectorsCell bodiesAuditory nerve inputExcitatory synaptic connectionsRetrograde neuronal tracingAuditory nerve fibersLocal axon collateralsNerve inputGlycine antibodiesExcitatory cellsViral vectorsExcitatory inputInhibitory inputsViral labelingAcoustic information processingLabeled cell bodiesPostsynaptic targetsNerve fibersBiotinylated dextran amine
2019
Nitric Oxide-Mediated Plasticity of Interconnections Between T-Stellate cells of the Ventral Cochlear Nucleus Generate Positive Feedback and Constitute a Central Gain Control in the Auditory System
Cao X, Lin L, Sugden A, Connors B, Oertel D. Nitric Oxide-Mediated Plasticity of Interconnections Between T-Stellate cells of the Ventral Cochlear Nucleus Generate Positive Feedback and Constitute a Central Gain Control in the Auditory System. Journal Of Neuroscience 2019, 39: 6095-6107. PMID: 31160538, PMCID: PMC6668202, DOI: 10.1523/jneurosci.0177-19.2019.Peer-Reviewed Original ResearchConceptsT stellate cellsNeuronal nitric oxide synthaseT-stellateVentral cochlear nucleusNitric oxide synthasePresynaptic firingIsofrequency laminaPostsynaptic cellAuditory nerve fiber inputsNitric oxideOxide synthaseAuditory nerve inputDuration of depolarizationAuditory nerve excitabilityNerve inputCochlear nucleusInferior colliculiNO-GCTonotopic arrayPrincipal cellsEvoked responsesBrainstem nucleiAscending pathwaysCell dendritesExcitatory networks
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