Jessica Furtado
Postdoctoral AssociateAbout
Research
Publications
2025
Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression
Furtado J, Zapadka T, Park H, Boyé K, Demb J, Eichmann A. Restoring compromised blood-retina-barrier integrity with Netrin-1 overexpression. Cellular And Molecular Life Sciences 2025, 82: 389. PMID: 41196411, PMCID: PMC12592616, DOI: 10.1007/s00018-025-05903-6.Peer-Reviewed Original ResearchConceptsBlood-retina barrierBlood-retina barrier integrityAge-related macular degenerationOxygen-induced retinopathyNetrin-1 overexpressionChoroidal neovascularizationNetrin-1Diabetic retinopathyVascular leakWet age-related macular degenerationBlood-retina barrier breakdownBlood-retina barrier functionLaser-induced choroidal neovascularizationVision-threatening retinal diseasesRetinal neuronal functionRetinal vascular diseasesBlood-retina-barrierMacular degenerationDR patientsVision lossRetinal angiogenesisRetinal diseasesNetrin-1 signalingDeficient retinasDisease progressionPIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations
Park H, Lee S, Furtado J, Robinson M, Antaya R, Oh S, Hong Y, Schwartz M, Young L, Eichmann A. PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations. Circulation 2025, 152: 599-615. PMID: 40665909, PMCID: PMC12270330, DOI: 10.1161/circulationaha.124.073630.Peer-Reviewed Original ResearchConceptsArteriovenous malformation formationType 2 hereditary hemorrhagic telangiectasiaArteriovenous malformationsHemorrhagic telangiectasiaKnockout miceSingle-cell RNA sequencingActivin receptor-like kinase 1Knockout mouse retinaHereditary hemorrhagic telangiectasiaMolecular hallmarksEndothelial nitric oxide synthaseReceptor-like kinase 1Piezo1 inhibitionNitric oxide synthaseMechanosensitive ion channel Piezo1Mutant endothelial cellsTelangiectasia lesionsMouse retinaVascular disordersSignal alterationsPharmacological inhibitionLoss-of-function variationPiezo1 expressionIon channel Piezo1Oxide synthase
2024
Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity
Furtado J, Geraldo L, Leser F, Bartkowiak B, Poulet M, Park H, Robinson M, Pibouin-Fragner L, Eichmann A, Boyé K. Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood–retina barrier integrity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2408674121. PMID: 39693351, PMCID: PMC11670198, DOI: 10.1073/pnas.2408674121.Peer-Reviewed Original ResearchConceptsBlood-retina barrierBlood-retina barrier integrityGene expressionScRNA-seqEndothelial cellsNetrin-1 receptor UNC5BNetrin-1Cell gene expression programsSingle-cell RNA sequencingDevelopment of retinal diseasesWnt signaling componentsGene expression programsTight junction proteinsMutant endothelial cellsScaffold proteinTranscriptional activityLoss of functionRNA sequencingRetinal arteriolesRetina endothelial cellsRetinal diseasesHomologue 1Expression programsReceptor UNC5BEndothelial subtypesMonoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells
Geraldo L, Xu Y, Mouthon G, Furtado J, Leser F, Blazer L, Adams J, Zhang S, Zheng L, Song E, Robinson M, Thomas J, Sidhu S, Eichmann A. Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells. Science Translational Medicine 2024, 16: eadn8388. PMID: 39565875, PMCID: PMC11822886, DOI: 10.1126/scitranslmed.adn8388.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCorneal NeovascularizationDisease Models, AnimalHumansIntercellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLMyeloid CellsNeovascularization, PathologicNerve Tissue ProteinsReceptors, ImmunologicRetinaRetinal NeovascularizationSignal TransductionConceptsOxygen-induced retinopathyPathological ocular neovascularizationCorneal neovascularizationMyeloid cellsOcular neovascularizationHeterogeneous population of myeloid cellsBlood-retina barrier integrityPopulation of myeloid cellsActivation of myeloid cellsMonoclonal antibodiesOcular neovascular diseasesBlinding eye diseaseHuman monoclonal antibodyExtracellular domainMouse model in vivoModel in vivoMAb treatmentMyeloid populationsOIR retinasNeovascular diseasesVision lossEye diseaseSlit-RoboSlit-Robo signalingBlocking antibodiesVascular development, remodeling and maturation
Furtado J, Eichmann A. Vascular development, remodeling and maturation. Current Topics In Developmental Biology 2024, 159: 344-370. PMID: 38729681, DOI: 10.1016/bs.ctdb.2024.02.001.Peer-Reviewed Original ResearchGene expression patternsKnowledge of vascular biologyControlling nutrient uptakeEarly embryonic developmentDysfunctional vasculatureVascular systemVascular system developmentSystem dysfunctionExpression patternsOrgan physiologyFunctional circulatory systemEndothelial cellsTherapeutic potentialEmbryonic developmentVascular system dysfunctionNutrient uptakeBlood vesselsSemi-permeable barrierVascular biologyHuman morbidity