Brian Fuehrlein, MD, PhD

2025

• Pharmacoepigenomics in Personalized Medicine: A Hypothesis-Generating Approach to Introduce CpG-PGx SNPs as New Candidates for a Systematic Insight into Genomic-Epigenomic-Phenomic-Pharmacogenomics (G-E-Ph-PGx) Axis

  Sharafshah A, Blum K, Lewandrowski K, Elman I, Fuehrlein B, Baron D, Pinhasov A, Thanos P, Fiorelli R, Schmidt S, Gardner E, Lorio M, Lewandrowski A, Gold M. Pharmacoepigenomics in Personalized Medicine: A Hypothesis-Generating Approach to Introduce CpG-PGx SNPs as New Candidates for a Systematic Insight into Genomic-Epigenomic-Phenomic-Pharmacogenomics (G-E-Ph-PGx) Axis. Journal Of Personalized Medicine 2025, 15: 579. PMID: 41440942, PMCID: PMC12734362, DOI: 10.3390/jpm15120579.

  Peer-Reviewed Original Research

  Concepts

• Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia

  Lewandrowski K, Blum K, Lewandrowski A, Thanos P, Pinhasov A, Sharafshah A, Baron D, Gold M, Dennen C, Elman I, Bowirrat A, Modestino E, Zeine F, Jafari N, Sunder K, Makale M, Giordano J, Gondre-Lewis M, Lindenau M, Fuehrlein B, Badgaiyan R, Levin C, Schmidt S, Fiorelli R. Correction: Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia. Frontiers In Public Health 2025, 13: 1737084. PMID: 41334398, PMCID: PMC12667608, DOI: 10.3389/fpubh.2025.1737084.

  Peer-Reviewed Original Research

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• Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia

  Lewandrowski K, Blum K, Lewandrowski A, Thanos P, Pinhasov A, Sharafshah A, Baron D, Gold M, Dennen C, Elman I, Bowirrat A, Modestino E, Zeine F, Jafari N, Sunder K, Makale M, Giordano J, Gondre-Lewis M, Lindenau M, Fuehrlein B, Badgaiyan R, Levin C, Schmidt S, Fiorelli R. Targeting pro-dopaminergic agonism to attenuate depression in patients displaying genetic/epigenetic predisposition to hypodopaminergia. Frontiers In Public Health 2025, 13: 1594872. PMID: 41080838, PMCID: PMC12512667, DOI: 10.3389/fpubh.2025.1594872.

  Peer-Reviewed Original Research

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• PGx-Based in silico Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse.

  Sharafshah A, Thanos P, Pinhasov A, Bowirrat A, Hanna C, Lewandrowski K, Rowan C, Elman I, Gold M, Dennen C, Modestino E, Badgaiyan R, Baron D, Fuehrlein B, Gupta A, Cadet J, Pollack A, Khalsa J, Makale M, Lewandrowski A, Blum K. PGx-Based in silico Analyses Identifies the Interactive Role of Genes, Glucose Metabolism and Dopaminergic Dysfunctional Pathways with Chronic Cocaine use and Misuse. Current Neuropharmacology 2025, 23 PMID: 40993956, DOI: 10.2174/011570159x390146250831143523.

  Peer-Reviewed Original Research

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• GWAS meta-meta-analysis and related analyses revealed a shared genetic background between ADHD and narcolepsy

  Modestino E, Sharafshah A, Lewandrowski K, Carey E, Mohankumar K, Thanos P, Pinhasov A, Bowirrat A, Baron D, Gold M, Elman I, Gardner E, Fuehrlein B, Zeine F, Jafari N, Dennen C, Lewandrowski A, Badgaiyan R, Blum K. GWAS meta-meta-analysis and related analyses revealed a shared genetic background between ADHD and narcolepsy. Academia Molecular Biology And Genomics 2025, 2 DOI: 10.20935/acadmolbiogen7751.

  Peer-Reviewed Original Research

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  Concepts

• Pre-addiction phenotype is associated with dopaminergic dysfunction: Evidence from 88.8 million genome-wide association study-based samples

  Blum K, Sharafshah A, Lewandrowski K, Schmidt S, Alvim Fiorelli R, Pinhasov A, Bowirrat A, Gold M, Gardner E, Thanos P, Fuehrlein B, Baron D, Elman I, Dennen C, Jafari N, Zeine F, Lewandrowski A, Makale M, Modestino E, Sunder K, Murphy K, Fliegelman C, Mahajan S, Mahajan Y, Badgaiyan R. Pre-addiction phenotype is associated with dopaminergic dysfunction: Evidence from 88.8 million genome-wide association study-based samples. Gene & Protein In Disease 2025, 4: 8090. DOI: 10.36922/gpd.8090.

  Peer-Reviewed Original Research

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• A Review of the Evidence Surrounding Popular Cognitive Enhancers

  Draghmeh K, Elmarasi M, Fuehrlein B. A Review of the Evidence Surrounding Popular Cognitive Enhancers. Current Psychopharmacologye 2025, 13 DOI: 10.2174/0122115560363501250609121229.

  Peer-Reviewed Original Research

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• Multi-Locus Pro-Dopaminergic Restoration of Reward Brain Circuitry in Reward Deficiency Rescinds Mono-Pharmaceutical Targeting.

  Blum K, Mohankumar K, Bagchi D, Lewandrowski K, Sharafshah A, Elman I, Gold M, Dennen C, Thanos P, Pinhasov A, Bowirrat A, Lewandrowski A, Baron D, Modestino E, Fuehrlein B, Khalsa J, Gastelu D, Fliegelman C, Sunder K, Murphy K, Makale M, Madigan M, Lindenau M, Swaroop A, Badgaiyan R. Multi-Locus Pro-Dopaminergic Restoration of Reward Brain Circuitry in Reward Deficiency Rescinds Mono-Pharmaceutical Targeting. EC Neurology 2025, 17 PMID: 41019658, PMCID: PMC12463428.

  Peer-Reviewed Original Research

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• A Review of Relapse in Opioid Use Disorder

  Draghmeh K, Gold M, Fuehrlein B. A Review of Relapse in Opioid Use Disorder. Current Addiction Reports 2025, 12: 58. DOI: 10.1007/s40429-025-00672-5.

  Peer-Reviewed Original Research

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• Exploring dopamine as the master regulator of brain circuitry and mental health genome

  Blum K, Braverman E, Sharafshah A, Elman I, Lewandrowski K, Bowirrat A, Pinhasov A, Thanos P, Gold M, Dennen C, Modestino E, Badgaiyan R, Baron D, Fuehrlein B, Sipple D, Ashford J, Sunder K, Makale M, Murphy K, Jafari N, Zeine F, Pollack A, Lewandrowski A, Khalsa J. Exploring dopamine as the master regulator of brain circuitry and mental health genome. Gene & Protein In Disease 2025, 5: 10.36922/gpd.6557. PMID: 40746483, PMCID: PMC12311831, DOI: 10.36922/gpd.6557.

  Peer-Reviewed Original Research

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