Cihan Halicigil, HCLD, PhD, MSc
Assistant Professor of Obstetrics, Gynecology and Reproductive SciencesCards
About
Research
Publications
2025
Assessing the efficacy of targeted enrichment protocol in PGT-M applications: a comprehensive analysis
Unsal E, Ozer L, Baltaci V, Duman T, Halicigil C, Koc Z, Saglam A, Buyuk P, Baris S, Aktuna S. Assessing the efficacy of targeted enrichment protocol in PGT-M applications: a comprehensive analysis. Journal Of Assisted Reproduction And Genetics 2025, 42: 3829-3838. PMID: 41091260, PMCID: PMC12640291, DOI: 10.1007/s10815-025-03676-2.Peer-Reviewed Original ResearchConceptsTargeted sequence enrichmentAllele dropout rateAllele dropoutPGT-MSequence enrichmentSTR markersSingle-gene disordersWGA samplesADO ratesTarget enrichmentMultiplex nested PCRMonogenic diseasesPreimplantation genetic testingGenetic testingSingle cellsGenesRetrospective data analysisNested PCRPCRPGT-APurposeThe aimEnrichmentSTRAllelesTest sensitivityLeveraging synthetic imagery and YOLOv8 for a novel colorimetric approach to paper-based point-of-care male fertility testing
Özarslan O, Tokyay B, Soylemez C, Birtek M, Uygun Z, Keles İ, Aydogan Mathyk B, Halicigil C, Tasoglu S. Leveraging synthetic imagery and YOLOv8 for a novel colorimetric approach to paper-based point-of-care male fertility testing. Sensors & Diagnostics 2025, 4: 336-344. DOI: 10.1039/d4sd00348a.Peer-Reviewed Original ResearchSynthetic imageryPaper-based systemObject detection algorithmDetection algorithmFertility monitorSynthetic dataDisease diagnosisPoint-of-careMale fertility testingSmartphone imagesCost-effective solutionSemen samplesSystem's abilityTraditional methodsFace stigmaLight conditionsPaper-based assayPOC diagnosticsFertility testsInfectious disease diagnosisBiochemical analysisImagesImageryPaper-based testSmartphoneChapter 21 Spaceflight implications for precision medicine in the field of obstetrics and gynecology and its subspecialties
Almukhtar L, Halicigil C, Patel S, Kohut A, Mathyk B. Chapter 21 Spaceflight implications for precision medicine in the field of obstetrics and gynecology and its subspecialties. 2025, 319-334. DOI: 10.1016/b978-0-443-22259-7.00016-3.ChaptersHealth outcomesField of obstetricsWomen's healthLong-term health outcomesUnique health challengesGynecologic oncologyImmediate health needsFetal health outcomesPrecision medicineMaternal-fetal medicineEffective careHealthcare deliveryHealth needsHealthcare approachLifestyle factorsPersonalized cancer therapyBone density lossMedical careHealth challengesPreventive medicineHealth issuesApplication of precision medicineIntegration of precision medicineHealthcareProactive healthcare
2024
Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space
Chaplia O, Mathyk B, Nichols-Burns S, Basar M, Halicigil C. Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space. Reproductive Biology And Endocrinology 2024, 22: 123. PMID: 39394617, PMCID: PMC11468284, DOI: 10.1186/s12958-024-01290-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAssisted Reproductive TechnologyIn vitro embryo developmentReproductive technologyRadiation-induced damageGamete handlingClinical embryologistsReproductive endocrinologistsTemperature limitEmbryo cultureReproductive medicineLow Earth orbitEmbryo developmentDeep space travelEarth orbitSpace environmentInterplanetary speciesEarth-boundMicrofluidic devicesCryopreservationGood laboratory practice for PGT-M: Turkish Society of Reproductive Medicine guidelines
Unsal E, Aktuna S, Arda B, Balaban B, Baltaci V, Bayram A, Bozdag G, Candan Z, Cetinkaya M, Ceylaner S, Findikli N, Goksever Celik H, Halicigil C, Kahraman S, Kayacaglayan M, Keles I, Kurtoglu A, Mutlu A, Ozgon G, Sukur Y, Tufekci M, Yakin K, Yelke H, Yildiz S, Ata B. Good laboratory practice for PGT-M: Turkish Society of Reproductive Medicine guidelines. Reproductive BioMedicine Online 2024, 49: 104378. PMID: 39321730, DOI: 10.1016/j.rbmo.2024.104378.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPrevention of errorsNeeds of practitionersPGT-M.Genetic testingReproductive healthPGT-MTurkish societyRate of consanguineous marriagesEthical issuesPolicy makersGenetic Diagnosis CenterConsanguineous marriagesPractical guideRecommendationsNon-governmental organizationsDiagnosis centerLaboratory accreditationGuidelinesMonogenic diseasesReproductive medicineHealthConsultationAccreditationCenterPreventionMaximizing Donor Egg Efficiency: Artificial Intelligence and Genetically Certified Oocytes
Aydin B, Hudkova D, Halicigil C. Maximizing Donor Egg Efficiency: Artificial Intelligence and Genetically Certified Oocytes. 2024, 471-490. DOI: 10.1007/978-3-031-58214-1_48.ChaptersDonor oocyte banksSelection of oocytesOocyte bankingOocyte vitrificationOocyte donationPGT-A methodsChances of implantationVitrification protocolPolar body biopsyUsable blastocystsEuploid blastocystsPGT-AAneuploid oocytesClinical pregnancyBody biopsyAneuploidy statusBiopsy methodClinical dataOncological problemSurvival rateOocytesPolar bodyPatientsMorphological evaluationMedical reasonsUnderstanding how space travel affects the female reproductive system to the Moon and beyond
Mathyk B, Imudia A, Quaas A, Halicigil C, Karouia F, Avci P, Nelson N, Guzeloglu-Kayisli O, Denbo M, Sanders L, Scott R, Basar M, Guevara-Cerdán A, Strug M, Monseur B, Kayisli U, Szewczyk N, Mason C, Young S, Tasoglu S, Costes S, Beheshti A. Understanding how space travel affects the female reproductive system to the Moon and beyond. Npj Women's Health 2024, 2: 20. DOI: 10.1038/s44294-024-00009-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHypothalamic-pituitary-gonadalFemale reproductive systemEndometrial receptivityReproductive endocrinologyHealthy live birthPreimplantation embryo developmentHypothalamic-pituitary-gonadal (HPG) axisFemale reproductive healthReproductive systemOvarian folliculogenesisCircadian rhythm changesLive birthsEmbryo implantationFemale reproductive endocrinologyEffects of space travelPregnancySpace travelReproductive healthEmbryo developmentRhythm changesAdverse effectsEndocrinologySuccessful transitionEffects of spaceflightInterplanetary species
2022
Automation in Clinical Embryology Laboratories — What is Next?
Halicigil C, Ogut M, Demirci U. Automation in Clinical Embryology Laboratories — What is Next? 2022, 105-126. DOI: 10.1142/9789811226106_0006.Peer-Reviewed Original ResearchDisposable paper-based microfluidics for fertility testing
Sarabi MR, Yigci D, Alseed MM, Mathyk BA, Ata B, Halicigil C, Tasoglu S. Disposable paper-based microfluidics for fertility testing. IScience 2022, 25: 104986. PMID: 36105592, PMCID: PMC9465368, DOI: 10.1016/j.isci.2022.104986.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntracytoplasmic sperm injectionAssisted Reproductive TechnologySevere male factor infertilitySuboptimal sperm parametersBurden of infertilityMale factor infertilityMale infertility casesPercent of couplesFactor infertilityInfertility casesReproductive ageInfertile casesSperm injectionInfertilityFertility testingSperm parametersReproductive medicineSperm concentrationReproductive technologiesFertility testsDiagnostic toolCare diagnostic toolSperm DNA analysisSperm motilitySperm enrichment
2021
Optimum identification of round spermatid in men with non‐obstructive azoospermia: A commentary
Bradshaw AW, Nikmehr B, Halicigil C, Stogner‐Underwood K, Sadri‐Ardekani H. Optimum identification of round spermatid in men with non‐obstructive azoospermia: A commentary. Andrology 2021, 9: 1817-1818. PMID: 34618410, DOI: 10.1111/andr.13113.Commentaries, Editorials and Letters
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