Stephanie Nichols-Burns, PhD, MS, HCLD
Associate Research ScientistCards
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Associate Research Scientist
Biography
Stephanie M. Nichols-Burns, PhD, joined Yale Fertility Center in 2017. She is an Associate Research Scientist and the IVF Laboratory Director of Research. She obtained her BS in Biology from The College of William and Mary, an MS in Marine Science from Moss Landing Marine Laboratories studying shark reproduction and early development, and her PhD at the University of New Orleans under one of the pioneers of human IVF. Her doctoral studies investigated aging effects on oocyte quality and reproductive senescence in a non-human primate model (macaques). After spending several years at the Caribbean Primate Research Center Reproductive Biology Program in Puerto Rico, she relocated overseas and investigated ovarian tissue cryopreservation in Erlangen, Germany with the first group in Germany to produce a live birth following reimplantation of cryopreserved ovarian tissue into a cancer survivor. Following these research experiences, she made a natural transition into clinical IVF where she has been able to apply her gained knowledge to helping patients achieve their dreams of parenthood.
Dr. Nichols-Burns is an active member of the American Society of Reproductive Medicine (ASRM), Society for Assisted Reproductive Technology (SART), Society of Reproductive Biologists and Technologists (SRBT), and New York Metropolitan Embryologist Society (NYMES). She is a member of the SART Executive Council as Chair of the Validation Committee. She is also a member of the SART Education Committee and Chair of the SRBT Education Committee. In addition, she participates in collaborative research, serves as a reviewer for multiple journals, and has published several original, peer-reviewed research articles.
Appointments
Obstetrics, Gynecology & Reproductive Sciences
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- PhD
- University of New Orleans (2007)
- MS
- San Jose State University (2001)
Research
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Research at a Glance
Yale Co-Authors
Publications Timeline
Cihan Halicigil, HCLD, PhD, MSc
David Seifer, MD
Denny Sakkas, PhD
Hugh Taylor, MD
Karen Jubanyik, MD
Murat Basar, PhD
Publications
2026
Clinical Embryology in the United States: Current Landscape and Considerations for Professional Development and Standardization
Gvakharia M, Sakkas D, Ezzati M, Ribeiro S, Sparks A, Go K, Bartolucci A, Celia G, Nichols-Burns S, Ali S, Baker M, Swain J, VerMilyea M, Albertini D, Jellerette-Nolan T, Jindal S, Embryology W, Gvakharia M, Sakkas D, Bartolucci A, Ali S, Baker M, Swain J, VerMilyea M, Albertini D, Jindal S. Clinical Embryology in the United States: Current Landscape and Considerations for Professional Development and Standardization. Fertility And Sterility 2026 PMID: 42176841, DOI: 10.1016/j.fertnstert.2026.05.159.Peer-Reviewed Original ResearchAltmetric
2024
Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space
Chaplia O, Mathyk B, Nichols-Burns S, Basar M, Halicigil C. Beyond Earth’s bounds: navigating the frontiers of Assisted Reproductive Technologies (ART) in space. Reproductive Biology And Endocrinology 2024, 22: 123. PMID: 39394617, PMCID: PMC11468284, DOI: 10.1186/s12958-024-01290-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords and ConceptsConceptsAssisted Reproductive TechnologyIn vitro embryo developmentReproductive technologyRadiation-induced damageGamete handlingClinical embryologistsReproductive endocrinologistsTemperature limitEmbryo cultureReproductive medicineLow Earth orbitEmbryo developmentDeep space travelEarth orbitSpace environmentInterplanetary speciesEarth-boundMicrofluidic devicesCryopreservation
2021
Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads
Mor A, Gardezi M, Jubanyik K, Simsek B, Seifer DB, Patrizio P, Esencan E, Imamoglu G, Zhang M, Nichols-Burns SM, Taylor HS. Miscarriage determination in first trimester based on alpha-fetoprotein extracted from sanitary pads. Fertility And Sterility 2021, 116: 462-469. PMID: 33461753, DOI: 10.1016/j.fertnstert.2020.10.006.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExtrauterine pregnancyVaginal bloodAlpha-fetoproteinOngoing pregnancyAFP levelsSanitary padsHigh alpha-fetoprotein levelsOngoing pregnancy groupProspective cohort studyAlpha-fetoprotein levelsAcademic medical centerPregnancy groupCohort studyMiscarriage casesFirst trimesterOffice visitsMedical CenterMAIN OUTCOMEPregnancyMedian levelsMiscarriageBloodAnxiety levelsAFPCharacteristic analysis
2019
A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement
Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns SM, Liu Y, Lo J, Kelk DA, Flores V, Gao XB, Seli E. A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement. Fertility And Sterility 2019, 113: 234-236. PMID: 31883732, DOI: 10.1016/j.fertnstert.2019.09.023.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntracytoplasmic sperm injectionICSI pipetteSperm injectionOocyte penetrationIntact oolemmaOocyte retrieval procedureMann-Whitney testMouse oocytesOocyte retrievalFemale miceMAIN OUTCOMEAcademic centersImmature oocytesHuman oocytesMature oocytesObjective toolMiceOocytesWomenVisual assessmentPipetteInjectionOolemmaStep 1GroupRepeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques
Abdulhaqq S, Martinez M, Kang G, Rodriguez I, Nichols S, Beaumont D, Joseph J, Azzoni L, Yin X, Wise M, Weiner D, Liu Q, Foulkes A, Münch J, Kirchhoff F, Coutifaris C, Tomaras G, Sariol C, Marx P, Li Q, Kraiselburd E, Montaner L. Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques. Nature Communications 2019, 10: 3753. PMID: 31434895, PMCID: PMC6704120, DOI: 10.1038/s41467-019-11814-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCD4+ T cellsFemale reproductive tractSemen exposureT cellsIncreased infiltration of CD4+ T cellsMale-to-female HIV transmissionCirculating CD4+ T cellsInfiltration of CD4+ T cellsExposure to semenEffect of semenNon-human primatesExpression of Mx1Anti-HIV mechanismsCervicovaginal mucosaSIVmac251 challengeSIVmac251 infectionCCR5 expressionIn vivo evidenceHIV acquisitionHIV infectionHIV transmissionAssociated with activationIncreased infiltrationRhesus macaquesReproductive tract
2015
Comparison of Whole Ovary Cryotreatments for Fertility Preservation
Lotz L, Hauenstein T, Nichols-Burns S, Strissel P, Hoffmann I, Findeklee S, Dittrich R, Beckmann M, Oppelt P. Comparison of Whole Ovary Cryotreatments for Fertility Preservation. Reproduction In Domestic Animals 2015, 50: 958-964. PMID: 26446780, DOI: 10.1111/rda.12615.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsWhole ovary cryopreservationWhole ovariesOvary cryopreservationSlow freezeFresh controlFertility preservationFollicle numberApoptotic folliclesHistological evaluationKrebs-RingerRadiotherapy treatmentPig ovariesOvariesSlow-freezing methodsSignificant differencesFunctional integrityFolliclesFurther investigationFresh tissueSpecimen jarOverall decreaseReproduktionsmedizin. Optimierte Transportbedingungen für konserviertes Ovarialgewebe
Lotz L, Schneider H, Nichols-Burns S, Hoffmann I, Oppelt P, Beckmann M, Dittrich R. Reproduktionsmedizin. Optimierte Transportbedingungen für konserviertes Ovarialgewebe. Geburtshilfe Und Frauenheilkunde 2015, 75: 218-221. DOI: 10.1055/s-0034-1396223.Peer-Reviewed Original Research
2014
Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques
Abdulhaqq S, Martinez M, Kang G, Foulkes A, Rodriguez I, Nichols S, Hunter M, Sariol C, Ruiz L, Ross B, Yin X, Speicher D, Haase A, Marx P, Li Q, Kraiselburd E, Montaner L. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2014, 65: 405-413. PMID: 24226059, PMCID: PMC3943721, DOI: 10.1097/qai.0000000000000047.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPlasmacytoid dendritic cellsSimian immunodeficiency virusT cell infiltrationDendritic cellsCD4 T cell lossCD4+ T cell infiltrationPlasmacytoid dendritic cell recruitmentRate of CD4 declineInfection of rhesus macaquesCD4 T cell infiltrationRate of viral replicationT cell lossPlasma viral loadRhesus macaquesCD4 T cellsCD4 T lymphocytesImmune cell infiltrationIndian rhesus macaquesAssociated with preventionCD4 countVaginal exposureCD4 declineImmunodeficiency virusVaginal tissueT cells
2009
Long-distance transportation of primate embryos developing in culture: a preliminary study
Nichols S, Harvey A, Gierbolini L, Gonzalez-Martinez J, Brenner C, Bavister B. Long-distance transportation of primate embryos developing in culture: a preliminary study. Reproductive BioMedicine Online 2009, 20: 365-370. PMID: 20093089, PMCID: PMC2829350, DOI: 10.1016/j.rbmo.2009.11.026.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPrimate embryosNon-human primate embryosPrimate Research CentreCleavage-stage embryosRhesus monkey embryosPreimplantation stagesMonkey embryosHuman infertilityCulture mediumAdvanced stageProcess of productionDevelopmental abilityTransport incubatorStem cellsDistant sitesProlonged cultureAdvanced stage of developmentPreliminary studyFresh culture mediumOocytesEmbryosIVFWayne State UniversityInfertilityOvernight courierInner Cell Mass Localization of NANOG Precedes OCT3/4 in Rhesus Monkey Blastocysts
Harvey A, Armant D, Bavister B, Nichols S, Brenner C. Inner Cell Mass Localization of NANOG Precedes OCT3/4 in Rhesus Monkey Blastocysts. Stem Cells And Development 2009, 18: 1451-1458. PMID: 19537945, PMCID: PMC3016202, DOI: 10.1089/scd.2009.0122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInner cell massInner cell masses of blastocystsRhesus monkey blastocystsOCT4 proteinExpression of CDX2Compacted morulaePig embryosBlastocystRegulatory markersOct4 expressionMouse embryosTrophectodermNanogNanog proteinCell massInvestigate local patternsPrimate developmentMiceRhesusMarkersExpressionLineage-specificEmbryosRegulatory mechanismsComplex interaction networks
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