2015
Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1
Whirledge SD, Garcia JM, Smith RG, Lamb DJ. Ghrelin Partially Protects Against Cisplatin-Induced Male Murine Gonadal Toxicity in a GHSR-1a-Dependent Manner1. Biology Of Reproduction 2015, 92: 76, 1-11. PMID: 25631345, PMCID: PMC4367966, DOI: 10.1095/biolreprod.114.123570.Peer-Reviewed Original ResearchConceptsTesticular cell deathTesticular damageGonadal toxicityEpididymal weightGrowth hormone secretagogue receptorDose-dependent side effectsCisplatin-induced cachexiaTime of euthanizationHigh cumulative doseBody weight homeostasisCell deathCisplatin-induced testicular damageNovel therapeutic approachesGonadotoxin exposurePermanent azoospermiaGhrelin administrationSubsequent infertilityChemotherapeutic drug cisplatinChemotherapeutic regimensCisplatin administrationGhrelin actionWeight homeostasisCumulative doseIntraperitoneal administrationSecretagogue receptor
2010
Glucocorticoids, stress, and fertility.
Whirledge S, Cidlowski JA. Glucocorticoids, stress, and fertility. Minerva Endocrinologica 2010, 35: 109-25. PMID: 20595939, PMCID: PMC3547681.Peer-Reviewed Original ResearchConceptsLevels of glucocorticoidsGonadal functionNormal brain developmentTestes/ovariesLevels of glucoseLife-long effectsFetal exposureMaternal exposureStress-related behaviorsAdrenal functionExogenous glucocorticoidsAdrenal axisGonadal axisNeuroendocrine functionGlucocorticoid inhibitionAnatomical sitesPrenatal stressElevated glucocorticoidsGlucocorticoidsPituitary glandReproductive functionBrain developmentStressful challengesFat breakdownMultiple tissues