2017
Dynamics of Base Excision Repair at the Maternal–Fetal Interface in Pregnancies Complicated by Preeclampsia
Tadesse S, Norwitz NG, Guller S, Arcuri F, Toti P, Norwitz ER, Kidane D. Dynamics of Base Excision Repair at the Maternal–Fetal Interface in Pregnancies Complicated by Preeclampsia. Reproductive Sciences 2017, 24: 856-864. PMID: 27707956, DOI: 10.1177/1933719116670519.Peer-Reviewed Original ResearchConceptsMaternal-fetal interfaceOxidative stressNormotensive controlsPlacental tissueHypoxia/reperfusion (H/R) modelPlacental endothelial dysfunctionPlacentas of womenHealthy control subjectsApyrimidinic endonuclease 1PE placental tissuesPregnancy ComplicatedEndothelial dysfunctionPreeclamptic womenPerinatal mortalityReperfusion modelControl subjectsDecidual cellsPathological basisVivo comparative studyPreeclampsiaMaternal cellsFetal cellsAPE1 expressionSignificant increaseWomen
2008
Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia
Guller S, Buhimschi CS, Y Y, Huang T, Yang L, Kuczynski E, Zambrano E, Lockwood CJ, Buhimschi IA. Placental expression of ceruloplasmin in pregnancies complicated by severe preeclampsia. Laboratory Investigation 2008, 88: 1057-1067. PMID: 18679377, PMCID: PMC2682720, DOI: 10.1038/labinvest.2008.74.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1Severe preeclampsiaReperfusion injurySFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Ischemia/reperfusion injuryLife-threatening syndromeSubsequent reperfusion injuryTerm control groupPathophysiology of preeclampsiaTyrosine kinase-1Activator inhibitor-1Release of factorsSignificant increasePresence of mRNAUpregulation of mRNACeruloplasmin mRNAPlacental damagePlacental factorsMicroarray gene profilingEndothelium dysfunctionPE placentasQuantitative real-time PCRIntervillous space