2024
Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia
Berbrier D, Adler T, Leone C, Paidas M, Stachenfeld N, Usselman C. Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia. AJP Heart And Circulatory Physiology 2024, 327: h140-h154. PMID: 38700469, DOI: 10.1152/ajpheart.00020.2024.Peer-Reviewed Original ResearchMuscle sympathetic nerve activitySystolic blood pressureResponse to acute stimuliIsometric handgrip exercise protocolMental stressHandgrip exercise protocolCardiovascular diseaseExercise-induced increaseEffective prevention strategiesAcute stimuliExercise protocolHistory of preeclampsiaBlood pressureIntegrated muscle sympathetic nerve activityElevated long-term riskElevated cardiovascular riskLong-term riskEnd-expiratory apneaSympathetic nerve activityPrevention strategiesHandgrip exerciseBlood pressure responseRisk factorsExaggerated pressorHealthy pregnancyThe effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis
Colburn A, Leone C, Alexander L, Stachenfeld N. The effect of acute estrogen suppression on cutaneous endothelium-dependent vasodilation in women with endometriosis. Physiology 2024, 39: 421. DOI: 10.1152/physiol.2024.39.s1.421.Peer-Reviewed Original ResearchEndothelium-dependent vasodilationEstrogen suppressionHealthy controlsLDF/mean arterial pressureSodium nitroprusside perfusionDose-response curveLaser Doppler flowmetryCardiovascular disease riskCutaneous vascular conductanceACh doseEndometriosis patientsPerfusion of acetylcholineMenstrual cycleIntradermal microdialysisSuppress estrogenEndothelial functionArterial pressureEndometriosisVasodilatory functionDoppler flowmetryVascular conductanceVasodilationMaximal vasodilationGraded perfusionEstrogenInhibition of NF-κB Activation Improves Non-Nitric Oxide-Mediated Cutaneous Microvascular Function in Reproductive-Aged Healthy Women
Content V, Williams A, Stachenfeld N, Alexander L. Inhibition of NF-κB Activation Improves Non-Nitric Oxide-Mediated Cutaneous Microvascular Function in Reproductive-Aged Healthy Women. Physiology 2024, 39: 562. DOI: 10.1152/physiol.2024.39.s1.562.Peer-Reviewed Original ResearchInhibition of NF-kB activationCutaneous microvascular functionNF-kB activationMicrovascular functionHealthy womenCutaneous vascular conductanceSalsalate treatmentInflammatory mechanismsImpact of systemic inflammationIncreasing concentrations of acetylcholineIntradermal microdialysis fibersDose-response protocolCohort of patientsMeasuring cutaneous blood flowPlacebo-controlled designHealthy control subjectsSystemic vascular functionNO synthase inhibitorHuman cutaneous circulationLaser-Doppler flowmetryDose-response curveRed blood cell fluxBlood cell fluxCardiovascular disease riskVentral forearm skin
2023
Call for papers: “Cardiovascular regulation during exercise: role of biological sex and consequences of aging”
Stone A, Grotle A, Stachenfeld N. Call for papers: “Cardiovascular regulation during exercise: role of biological sex and consequences of aging”. AJP Regulatory Integrative And Comparative Physiology 2023, 326: r89-r90. PMID: 38145291, DOI: 10.1152/ajpregu.00285.2023.Peer-Reviewed Original ResearchConceptsRegulationDifferent perspectives on women’s health, nutrition and endurance exercise
Charkoudian N, Lee J, Giersch G, DiPietro L, Stachenfeld N. Different perspectives on women’s health, nutrition and endurance exercise. Journal Of The International Society Of Sports Nutrition 2023, 20: 2286286. PMID: 38018805, PMCID: PMC11018311, DOI: 10.1080/15502783.2023.2286286.Peer-Reviewed Original ResearchGuidelines on the use of sex and gender in cardiovascular research
Usselman C, Lindsey M, Robinson A, Habecker B, Taylor C, Merryman W, Kimmerly D, Bender J, Regensteiner J, Moreau K, Pilote L, Wenner M, O'Brien M, Yarovinsky T, Stachenfeld N, Charkoudian N, Denfeld Q, Moreira-Bouchard J, Pyle W, DeLeon-Pennell K. Guidelines on the use of sex and gender in cardiovascular research. AJP Heart And Circulatory Physiology 2023, 326: h238-h255. PMID: 37999647, PMCID: PMC11219057, DOI: 10.1152/ajpheart.00535.2023.Peer-Reviewed Original ResearchThe Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
Hunter S, Angadi S, Bhargava A, Harper J, Hirschberg A, Levine B, Moreau K, Nokoff N, Stachenfeld N, Bermon S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Translational Journal Of The American College Of Sports Medicine 2023, 8: 1-33. DOI: 10.1249/tjx.0000000000000236.Peer-Reviewed Original ResearchSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomenThe Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine
HUNTER S, ANGADI S, BHARGAVA A, HARPER J, HIRSCHBERG A, LEVINE B, MOREAU K, NOKOFF N, STACHENFELD N, BERMON S. The Biological Basis of Sex Differences in Athletic Performance: Consensus Statement for the American College of Sports Medicine. Medicine & Science In Sports & Exercise 2023, 55: 2328-2360. PMID: 37772882, DOI: 10.1249/mss.0000000000003300.Peer-Reviewed Original ResearchConceptsSex steroid hormonesConsensus statementAthletic performanceEndogenous sex steroid hormonesSex differencesSteroid hormonesOnset of pubertyExercise trainingMuscle strengthAcute boutFundamental sex differencesSex hormonesAmerican CollegeParticular testosteroneAdult menSports medicineTraining statusHigh-impact studiesHormoneSimilar ageNonphysiological factorsPrimary determinantMalesBiological basisWomenEffects Of A Randomized Placebo-Controlled Oral Salsalate Intervention On Flow-Mediated Dilation In Women With Endometriosis
Kirby N, Williams A, Content V, Wolf S, Dillon G, Stachenfeld N, Alexander L. Effects Of A Randomized Placebo-Controlled Oral Salsalate Intervention On Flow-Mediated Dilation In Women With Endometriosis. Medicine & Science In Sports & Exercise 2023, 55: 398-399. DOI: 10.1249/01.mss.0000983544.89010.be.Peer-Reviewed Original ResearchComment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”
Colburn A, Stachenfeld N. Comment on “Effects of biological sex and oral contraceptive pill use on cutaneous microvascular endothelial function and nitric oxide-dependent vasodilation in humans”. Journal Of Applied Physiology 2023, 135: 485-486. PMID: 37541850, DOI: 10.1152/japplphysiol.00335.2023.Peer-Reviewed Original ResearchTestosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPSex Hormones and Environmental Factors Affecting Exercise
Wenner M, Stachenfeld N. Sex Hormones and Environmental Factors Affecting Exercise. 2023, 113-134. DOI: 10.1007/978-3-031-21881-1_5.ChaptersSex hormone effectsSex hormonesHormone exposureHormone effectsFluid regulationIndividual sex hormonesReproductive hormone exposurePolycystic ovary syndromeMenstrual cycle differencesSex hormone exposureOnset of thirstCore temperatureOnset of sweatingOvary syndromeExercise trainingHormonal contraceptivesNumerous health benefitsMenstrual cycleHormonal profileReproductive hormonesFluid balancePhysical activityPhysiological systemsHigher sweat ratesSweating thresholdTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgensLetter to the Editor in response to: Microvascular endothelial function following the cessation of long‐term oral contraceptive pill use: A case report
Kirby N, Stachenfeld N, Alexander L. Letter to the Editor in response to: Microvascular endothelial function following the cessation of long‐term oral contraceptive pill use: A case report. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2023, 108: 1092-1094. PMID: 37098953, PMCID: PMC10836611, DOI: 10.1113/ep091174.Commentaries, Editorials and LettersEffects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Effects of androgen excess and body mass index on endothelial function in women with polycystic ovary syndrome. Journal Of Applied Physiology 2023, 134: 868-878. PMID: 36861670, DOI: 10.1152/japplphysiol.00583.2022.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeEndothelial dysfunctionEndothelial functionOvary syndromeAndrogen excessLean womenObese womenEstradiol supplementationLow flow-mediated constrictionOW/OB groupOverweight/obese womenMarked endothelial dysfunctionSevere endothelial dysfunctionFree testosterone levelsBody mass indexFlow-mediated dilation (FMD) testFree testosteroneMass indexReactive hyperemiaOB groupTestosterone levelsHealth differEndothelial pathophysiologyDysfunctionAndrogens
2022
Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies
Huang T, Howse F, Stachenfeld N, Usselman C. Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies. AJP Heart And Circulatory Physiology 2022, 324: h33-h46. PMID: 36426884, DOI: 10.1152/ajpheart.00399.2022.Peer-Reviewed Original ResearchConceptsMenstrual cycleGonadal hormonesFemale participantsVenous blood samplesGonadal hormone fluctuationsPrimary gonadalVascular functionBlood concentrationsCardiovascular diseaseHormone assessmentSerial measurementsHormone fluctuationsHormone monitoringBlood samplesStudy designGold standard measurementHuman physiology researchHormoneInclusion of femalesSalivaryResearch studiesCardiovascular researchersParticipantsFemalesSeven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis
Dillon GA, Stanhewicz AE, Serviente C, Flores VA, Stachenfeld N, Alexander LM. Seven days of statin treatment improves nitric-oxide mediated endothelial-dependent cutaneous microvascular function in women with endometriosis. Microvascular Research 2022, 144: 104421. PMID: 35970408, PMCID: PMC9527706, DOI: 10.1016/j.mvr.2022.104421.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationLaser Doppler fluxEndothelial functionCardiovascular diseaseOral atorvastatinExerts potent anti-inflammatory effectsEndothelium-dependent agonist acetylcholineShort-term statin administrationPotent anti-inflammatory effectsIntradermal microdialysis perfusionNO-dependent dilationImpaired endothelial functionMicrovascular endothelial functionCutaneous microvascular functionCutaneous vascular conductanceAnti-inflammatory effectsNO-dependent vasodilationNO synthase inhibitorDose-response curveStatin therapyAdjunctive therapyAtorvastatin treatmentCVD riskEndothelial dysfunctionStatin administrationAre there sex differences in risk for exertional heat stroke? A translational approach
Giersch GEW, Garcia CK, Stachenfeld N, Charkoudian N. Are there sex differences in risk for exertional heat stroke? A translational approach. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2022, 107: 1136-1143. PMID: 35598159, DOI: 10.1113/ep090402.Peer-Reviewed Original ResearchConceptsExertional heat strokeHeat strokeRisk factorsTranslational approachCentral nervous system dysfunctionNervous system dysfunctionFemale sex hormonesSex differencesHuman researchOrgan damageFatal conditionSystem dysfunctionSex hormonesPhysical activityStrokeTranslational modelOccupational workersRiskMilitary personnelAnimalsTreatmentHuman modelReviewFuture investigationsPhysiological differencesEndothelial (Dys)function in Women With Androgen Excess Polycystic Ovary Syndrome: Effects of Body Composition and Ethinyl Estradiol Supplementation
Berbrier D, Leone C, Adler T, Bender J, Taylor H, Stachenfeld N, Usselman C. Endothelial (Dys)function in Women With Androgen Excess Polycystic Ovary Syndrome: Effects of Body Composition and Ethinyl Estradiol Supplementation. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.0r847.Peer-Reviewed Original ResearchOW/OB womenFlow-mediated dilationPolycystic ovary syndromeOB womenEndothelial functionEndothelial dysfunctionLean womenOvary syndromeEstradiol supplementationForms of PCOSConduit vessel endothelial functionOverweight/obese womenHealthy lean womenImpaired endothelial functionResult of obesityVessel endothelial functionFMD changesFMD responseObese womenFree testosteroneOb controlsReactive hyperemiaBody compositionEE supplementationDysfunctionPolycystic ovary syndrome and black race are associated with increased blood pressure
Okifo N, Pal L, Mushi M, Stachenfeld N. Polycystic ovary syndrome and black race are associated with increased blood pressure. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r3724.Peer-Reviewed Original ResearchOlder reproductive age womenReproductive-age womenNon-obese groupPolycystic ovary syndromeMultivariable linear regression modelsBlood pressureAge womenObese groupBlack raceBP indicesOvary syndromeRacial breakdownDiagnosis of PCOSNon-obese womenCardiovascular disease riskMultivariable linear regressionType II diabetesLinear regression modelsGreater systolicTubal infertilityIndependent predictorsCommon endocrinopathyRegression modelsBP measurementsPCOS