Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells
Shapiro JP, Basar M, Kayisli UA, Guzeloglu-Kayisli O, Huang S, Suarez AA, Ozer HG, Schatz F, Lockwood CJ. Mass spectrometry identification of potential mediators of progestin-only contraceptive-induced abnormal uterine bleeding in human endometrial stromal cells. Contraception 2014, 91: 253-260. PMID: 25529278, PMCID: PMC4395468, DOI: 10.1016/j.contraception.2014.11.005.Peer-Reviewed Original ResearchConceptsHuman endometrial stromal cellsAbnormal uterine bleedingEndometrial stromal cellsUterine bleedingStanniocalcin-1Cultured human endometrial stromal cellsStromal cellsMicroarray analysisEndometrial biopsyTubal metaplasiaMRNA microarray analysisSide effectsLAPCComplex biological responseEtonogestrelHypoxia treatmentProgestinsHypoxiaPrimary culturesPotential mediatorsPotential targetProtein mediatorsBleedingExpression levelsMedium supernatantHypertension alters phosphorylation of VASP in brain endothelial cells
Arlier Z, Basar M, Kocamaz E, Kiraz K, Tanriover G, Kocer G, Arlier S, Giray S, Nasırcılar S, Gunduz F, Senturk U, Demir N. Hypertension alters phosphorylation of VASP in brain endothelial cells. International Journal Of Neuroscience 2014, 125: 288-297. PMID: 24894047, DOI: 10.3109/00207454.2014.930740.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBrainCase-Control StudiesCell Adhesion MoleculesCells, CulturedDisease Models, AnimalEndothelial CellsExercise TherapyGene Expression RegulationHumansHypertensionHypoxiaMicrofilament ProteinsOxygenPhosphoproteinsPhosphorylationRatsRats, Inbred SHRRats, Inbred WKYSerineStatistics, NonparametricSwimmingTime FactorsConceptsBrain endothelial cellsVASP expressionEndothelial cellsVasodilator-stimulated phosphoproteinVASP phosphorylationWestern blottingHypertension-induced alterationsIndirect salutary effectsEffects of hypertensionEffects of exerciseNormoxic endothelial cellsEndothelial barrier functionWKY ratsEndothelial changesTissue hypoxiaCerebral vasculatureHypertensionSalutary effectsExercise conditionsBarrier functionVascular systemExerciseAlters phosphorylationImmunocytochemistryBlotting