2014
Hypertension alters phosphorylation of VASP in brain endothelial cells
Arlier Z, Basar M, Kocamaz E, Kiraz K, Tanriover G, Kocer G, Arlier S, Giray S, Nasırcılar S, Gunduz F, Senturk U, Demir N. Hypertension alters phosphorylation of VASP in brain endothelial cells. International Journal Of Neuroscience 2014, 125: 288-297. PMID: 24894047, DOI: 10.3109/00207454.2014.930740.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureBrainCase-Control StudiesCell Adhesion MoleculesCells, CulturedDisease Models, AnimalEndothelial CellsExercise TherapyGene Expression RegulationHumansHypertensionHypoxiaMicrofilament ProteinsOxygenPhosphoproteinsPhosphorylationRatsRats, Inbred SHRRats, Inbred WKYSerineStatistics, NonparametricSwimmingTime FactorsConceptsBrain endothelial cellsVASP expressionEndothelial cellsVasodilator-stimulated phosphoproteinVASP phosphorylationWestern blottingHypertension-induced alterationsIndirect salutary effectsEffects of hypertensionEffects of exerciseNormoxic endothelial cellsEndothelial barrier functionWKY ratsEndothelial changesTissue hypoxiaCerebral vasculatureHypertensionSalutary effectsExercise conditionsBarrier functionVascular systemExerciseAlters phosphorylationImmunocytochemistryBlotting
2012
Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis
Cakmak H, Basar M, Seval-Celik Y, Osteen KG, Duleba AJ, Taylor HS, Lockwood CJ, Arici A. Statins Inhibit Monocyte Chemotactic Protein 1 Expression in Endometriosis. Reproductive Sciences 2012, 19: 572-579. PMID: 22267540, PMCID: PMC3439122, DOI: 10.1177/1933719111430998.Peer-Reviewed Original ResearchConceptsCultured endometriotic cellsMonocyte chemotactic protein-1 expressionChemotactic protein-1 expressionMCP-1 productionEndometriotic cellsProtein-1 expressionEndometriotic implantsMouse modelMCP-1 messenger RNA expressionExerts anti-inflammatory effectsAnti-inflammatory effectsEffect of statinsAnti-inflammatory propertiesMCP-1 expressionMevalonate pathwayDose-dependent inhibitionNude mouse modelMessenger RNA expressionDose-dependent mannerEctopic endometriumEndometrial cellsPeritoneal surfaceStatinsPotential treatmentInhibitory effect
2010
The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia
Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia. American Journal Of Pathology 2010, 177: 2472-2482. PMID: 20829438, PMCID: PMC2966804, DOI: 10.2353/ajpath.2010.091247.Peer-Reviewed Original ResearchConceptsGranulocyte-macrophage colony-stimulating factorColony-stimulating factorPathogenesis of preeclampsiaDendritic cellsDecidual cellsFirst trimester human decidual cellsGranulocyte-macrophage colony-stimulating factor (GM-CSF) expressionGenesis of preeclampsiaSystemic inflammatory stateInterleukin-1 βTumor necrosis factorHuman decidual cellsColony-stimulating factor expressionFactor expression levelsColony-stimulating factor productionGM-CSF expressionGranulocyte-macrophage colony-stimulating factor productionPreeclamptic deciduaShallow placentationInflammatory stateHuman deciduaNecrosis factorMurine modelPreeclampsiaMouse model