2022
Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample
Beijers R, Thije I, Bolhuis E, O'Donnell K, Tollenaar M, Shalev I, Hastings W, MacIsaac J, Lin D, Meaney M, Kobor M, Belsky J, de Weerth C. Cumulative risk exposure and child cellular aging in a Dutch low‐risk community sample. Psychophysiology 2022, 60: e14205. PMID: 36323627, DOI: 10.1111/psyp.14205.Peer-Reviewed Original ResearchConceptsChildhood risk exposuresLow-risk community sampleAge 6Cortisol reactivityAge 10Cumulative risk exposureCommunity sampleCellular agingPhysical health outcomesHealth outcomesStressor exposureTelomere lengthSecondary findingsLater lifeChild cortisol reactivityRegression analysisSignificant main effectFurther investigationExposurePositive correlationMore researchStrong conclusionsAgingBiomarkers
2018
The early care environment and DNA methylome variation in childhood
Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood. Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylationDNA methylationGenetic variationGenetic dataEarly care environmentsMethylome variationInfant attachment styleInfant attachmentEpigenetic modificationsAttachment styleBuccal epithelial samplesMethylationMolecular signaturesPrenatal adversityGenetic contributionInfant developmentChild genetic variationInfant cognitive developmentDisorganized attachment styleLater mental health problemsNegative effectsEarly intervention programsChild mental healthMental health problemsCognitive development