2013
Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis
Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. Journal Of Clinical Investigation 2013, 123: 5082-5097. PMID: 24177422, PMCID: PMC3859420, DOI: 10.1172/jci67752.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDBlood VesselsCadherinsCells, CulturedEar, ExternalEndothelium, VascularHindlimbHuman Umbilical Vein Endothelial CellsHumansIschemiaMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNeovascularization, PhysiologicNeuropilinsProtein Tyrosine Phosphatase, Non-Receptor Type 1Protein Tyrosine Phosphatase, Non-Receptor Type 2Retinal VesselsRNA InterferenceRNA, Small InterferingVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2ZebrafishZebrafish ProteinsConceptsSmooth muscle cell-derived neuropilin-like proteinAberrant blood vessel formationNormal vascular developmentProtein tyrosineTC-PTPTransmembrane proteinTherapeutic targetBlood vessel formationVEGF responseNegative regulatorDevelopmental angiogenesisVEGFR-2Vascular developmentAttractive therapeutic targetESDNAngiogenesis regulationVE-cadherinVessel formationEC proliferationComplex formationRegulatorProteinNeuropilin expressionVEGF receptorsEndothelial VEGF
2000
CD28 and LFA‐1 contribute to cyclosporin A‐resistant T cell growth by stabilizing the IL‐2 mRNA through distinct signaling pathways
Geginat J, Clissi B, Moro M, Dellabona P, Bender J, Pardi R. CD28 and LFA‐1 contribute to cyclosporin A‐resistant T cell growth by stabilizing the IL‐2 mRNA through distinct signaling pathways. European Journal Of Immunology 2000, 30: 1136-1144. PMID: 10760803, DOI: 10.1002/(sici)1521-4141(200004)30:4<1136::aid-immu1136>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDB7-2 AntigenCalcineurinCD28 AntigensCells, CulturedCyclosporineCytoskeletonDendritic CellsDNA-Binding ProteinsDrug SynergismHumansIntercellular Adhesion Molecule-1Interleukin-2Lymphocyte ActivationLymphocyte Function-Associated Antigen-1Membrane GlycoproteinsMitogen-Activated Protein KinasesNFATC Transcription FactorsNF-kappa BNuclear ProteinsPromoter Regions, GeneticProtein BindingRNA StabilityRNA, MessengerSignal TransductionSuperantigensT-LymphocytesTranscription FactorsConceptsIL-2 mRNALFA-1ICAM-1IL-2 dependentT cell proliferationSubsequent T cell proliferationCostimulatory molecule CD28TCR-induced proliferationSignaling pathwaysT cell growthIL-2 transcriptsGraft rejectionDendritic cellsIL-2Clinical transplantationT lymphocytesMolecule CD28Primary T lymphocytesNF-kappaBCD28Distinct signaling pathwaysLower transcriptional rateDifferent signaling pathwaysProtein kinase activationCell proliferation
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammation
1992
Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes.
Pardi R, Inverardi L, Rugarli C, Bender J. Antigen-receptor complex stimulation triggers protein kinase C-dependent CD11a/CD18-cytoskeleton association in T lymphocytes. Journal Of Cell Biology 1992, 116: 1211-1220. PMID: 1346786, PMCID: PMC2289356, DOI: 10.1083/jcb.116.5.1211.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdultAntigens, CDAntigens, Differentiation, T-LymphocyteCD18 AntigensCD3 ComplexChild, PreschoolCytoskeletal ProteinsCytoskeletonHumansLymphocyte ActivationLymphocyte Function-Associated Antigen-1PhosphorylationProtein Kinase CReceptors, Antigen, T-CellSignal TransductionT-LymphocytesConceptsProtein kinase C inhibitor staurosporineProtein kinase CT cell receptor complexCell receptor complexC inhibitor staurosporineHigh avidity stateSignal transductionCytoskeletal rearrangementsActin polymerizationIntercellular adhesionIntracellular signalsF-actinMolecular eventsInhibitor staurosporineKinase CAvidity stateLFA-1Membrane fractionCD11a/CD18 complexTCR complexTCR crosslinkingPKC desensitizationComplex activationReceptor complexFluorescence microscopy
1991
Endothelial cell class II HLA expression induced by cytotoxic lymphocytes is regulated by genetically determined differences in CD11a/CD18.
Bender J, Tackett L, Pardi R. Endothelial cell class II HLA expression induced by cytotoxic lymphocytes is regulated by genetically determined differences in CD11a/CD18. Transplantation Proceedings 1991, 23: 99-101. PMID: 1671312.Peer-Reviewed Original Research
1990
Natural killer lines and clones with apparent antigen specificity.
Suzuki N, Bianchi E, Bass H, Suzuki T, Bender J, Pardi R, Brenner C, Larrick J, Engleman E. Natural killer lines and clones with apparent antigen specificity. Journal Of Experimental Medicine 1990, 172: 457-462. PMID: 2142719, PMCID: PMC2188332, DOI: 10.1084/jem.172.2.457.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigen-Antibody ComplexAntigens, CDAntigens, DifferentiationAntigens, Differentiation, T-LymphocyteCD3 ComplexCell LineCells, CulturedClone CellsCytotoxicity, ImmunologicFlow CytometryHumansKiller Cells, NaturalMacromolecular SubstancesReceptors, Antigen, T-CellReceptors, FcReceptors, IgGConceptsLymphoblastoid cell linesAllogeneic lymphoblastoid cell linesTCR alpha/betaClass II MHC antigensIL-2-containing mediumPotent cytolytic activityNK cellsAllogeneic targetsCD3 lymphocytesMHC antigensCytolytic activityAntigen specificityTCR-beta transcriptsCD3Class ICD16CD3 epsilonSelective killingNorthern blot analysisBlot analysisCell linesK562 cellsK562 erythroleukemia cellsChain transcriptsMAbs