2012
A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis
Grechukhina O, Petracco R, Popkhadze S, Massasa E, Paranjape T, Chan E, Flores I, Weidhaas JB, Taylor HS. A polymorphism in a let‐7 microRNA binding site of KRAS in women with endometriosis. EMBO Molecular Medicine 2012, 4: 206-217. PMID: 22307873, PMCID: PMC3376847, DOI: 10.1002/emmm.201100200.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsKRAS-variantCultured endometrial stromal cellsStromal cellsAbnormal endometrial growthDe novo endometriosisProgesterone receptor levelsRelatives of womenEndometrial xenograftsKRAS resultsLCS6 polymorphismEndometrial growthReproductive ageKRAS mutationsReceptor levelsMurine modelEndometriosisEndometriosis riskControl populationVariant allelesKRAS mRNAProtein expressionKRASWomenKRAS protein
2003
Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10
Troy PJ, Daftary GS, Bagot CN, Taylor HS. Transcriptional Repression of Peri-Implantation EMX2 Expression in Mammalian Reproduction by HOXA10. Molecular And Cellular Biology 2003, 23: 1-13. PMID: 12482956, PMCID: PMC140663, DOI: 10.1128/mcb.23.1.1-13.2003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCells, CulturedEmbryonic DevelopmentEndometriumEstradiolFemaleHomeobox A10 ProteinsHomeodomain ProteinsHumansMammalsMenstrual CycleMiceMutationOligonucleotides, AntisensePregnancyProgesteroneRecombinant ProteinsRegulatory Sequences, Nucleic AcidRepressor ProteinsReproductionTranscription FactorsTranscription, GeneticConceptsTranscriptional repressionMammalian reproductionNegative transcriptional regulationDivergent homeobox genesPossible evolutionary implicationsSite-directed mutagenesisTransient transfection assaysNegative regulatory relationshipDrosophila orthologUrogenital tract developmentDirection of regulationTranscriptional regulationEvolutionary implicationsGene relationshipsHomeobox genesTranscriptional activationTranscriptional targetsRegulatory regionsEmpty spiraclesRegulatory relationshipsDeletional analysisDNase IEMX2 mRNAConstitutive expressionNorthern analysis