2024
A retrospective analysis of factors associated with deep contraceptive implant removals compared to superficial removals
Kendall P, Bresnitz W, Huang J, Sheeder J, Lazorwitz A. A retrospective analysis of factors associated with deep contraceptive implant removals compared to superficial removals. Contraception 2024, 137: 110486. PMID: 38754757, DOI: 10.1016/j.contraception.2024.110486.Peer-Reviewed Original ResearchContraceptive implant removalLower body mass indexBody mass indexImplant removalSuperficial removalWeight gainAssociated with younger ageRetrospective cohort studyMann-Whitney U testMultivariate logistic regressionAssociated with increased oddsFactors associated with increased likelihoodHealth record reviewContraceptive implantsImplant exchangeFischer's exactElectronic health record reviewImplant useComparing patientsRetrospective analysisMass indexCohort studyPatient characteristicsRemoval groupInserting contraceptive implants
2023
An exploratory study on the possible association of serum etonogestrel concentrations with mood concerns and symptoms among contraceptive implant users
Diamond B, Sheeder J, Lazorwitz A. An exploratory study on the possible association of serum etonogestrel concentrations with mood concerns and symptoms among contraceptive implant users. Contraception 2023, 129: 110298. PMID: 37802462, PMCID: PMC10842501, DOI: 10.1016/j.contraception.2023.110298.Peer-Reviewed Original ResearchConceptsMood-related side effectsContraceptive implant usersENG implant usersInter-individual variabilitySide effectsImplant usersEtonogestrel contraceptive implant usersMood changesWide inter-individual variabilitySerum etonogestrel concentrationsPHQ-9 scoresSerum drug levelsLiquid chromatography-mass spectrometry assaySubset of participantsEtonogestrel concentrationsPrimary outcomePharmacokinetic variabilityMood concernsBaseline questionnairePHQ-9Blood drawDrug levelsMood symptomsImplant usePossible association
2022
P077Pilot study on a novel, alternative subdermal scapular insertion site for the etonogestrel contraceptive implant
Clure C, Sheeder J, Lazorwitz A. P077Pilot study on a novel, alternative subdermal scapular insertion site for the etonogestrel contraceptive implant. Contraception 2022, 116: 91. DOI: 10.1016/j.contraception.2022.09.101.Peer-Reviewed Original ResearchEtonogestrel contraceptive implantContraceptive implantsENG implantENG levelsSide effectsMedian pain scoreTime pointsReproductive-aged womenScapular insertionPain scoresSite painMedian ageMedian BMIImplant useInferior edgeInsertion siteWeek twoYears of useFirst weekPilot studyImplant usersPharmacokineticsImplantsFirst yearWeeksEffect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users
Lazorwitz A, Pena M, Sheeder J, Teal S. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics And Gynecology 2022, 139: 579-587. PMID: 35594123, PMCID: PMC9140306, DOI: 10.1097/aog.0000000000004697.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsContraceptive implant usersEtonogestrel concentrationsBody mass indexPg/Median ageImplant usersEnzyme-inducing antiepileptic drugsMedian body mass indexEffects of topiramateMean percent changeParticipants' median ageOvulatory suppressionTopiramate therapyMedian durationTopiramate useEtonogestrel implantsPharmacokinetic interactionsHealthy womenAntiepileptic drugsMass indexNoninferiority studyImplant useMass spectrometry assayPercent change
2020
An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users
Lazorwitz A, Dindinger E, Harrison M, Aquilante C, Sheeder J, Teal S. An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users. Contraception 2020, 102: 180-185. PMID: 32407811, PMCID: PMC7483263, DOI: 10.1016/j.contraception.2020.05.002.Peer-Reviewed Original ResearchConceptsBody mass indexEtonogestrel contraceptive implant usersEstrogen receptor 1Contraceptive implant usersContraceptive implant useWeight gainImplant useWeight changeImplant insertionEnrollment body mass indexMedian body mass indexGenetic variantsReproductive-aged womenMedian weight changeImplant usersExogenous steroid hormonesEstrogen receptor 1 geneReceptor 1 genePhysiologic plausibilityEtonogestrel implantsMetabolic syndromeMedical recordsContraceptive counselingRetrospective analysisIndividualized counseling
2019
Relationship Between Etonogestrel Concentrations and Bleeding Patterns in Contraceptive Implant Users.
Lazorwitz A, Aquilante C, Dindinger E, Harrison M, Sheeder J, Teal S. Relationship Between Etonogestrel Concentrations and Bleeding Patterns in Contraceptive Implant Users. Obstetrics And Gynecology 2019, 134: 807-813. PMID: 31503152, PMCID: PMC6768730, DOI: 10.1097/aog.0000000000003452.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsContraceptive implant usersEtonogestrel concentrationsOral contraceptive pillsRelated side effectsAbnormal bleedingSide effectsBleeding patternsContraceptive pillsContraceptive implantsBothersome bleedingImplant usersProspective cross-sectional studyReproductive-aged womenMultivariable logistic regressionHormonal contraceptive methodsCross-sectional studyDiscontinuation ratesEtonogestrel implantsPatient satisfactionPill prescriptionMedical recordsBleedingContraceptive methodsImplant useRelationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users
Lazorwitz A, Aquilante C, Sheeder J, Guiahi M, Teal S. Relationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users. Contraception 2019, 100: 37-41. PMID: 30980827, PMCID: PMC6589369, DOI: 10.1016/j.contraception.2019.03.045.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsContraceptive implant usersBody mass indexBlack/African American raceEtonogestrel concentrationsAfrican American raceMass indexPatient characteristicsImplant useEtonogestrel levelsImplant usersAmerican raceHispanic/Latina ethnicityMedian body mass indexSerum etonogestrel levelsEtonogestrel contraceptive implantSide effect profileReproductive-age womenCertain patient characteristicsIndividual patient characteristicsMajority of womenNon-significant increaseLatina ethnicityMedian ageSerum concentrationsInfluence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.
Lazorwitz A, Aquilante C, Oreschak K, Sheeder J, Guiahi M, Teal S. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics And Gynecology 2019, 133: 783-794. PMID: 30870275, PMCID: PMC6448146, DOI: 10.1097/aog.0000000000003189.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsBody mass indexContraceptive implant usersEtonogestrel concentrationsSteroid hormone metabolismImplant useGenetic variantsHepatic enzyme inducersReproductive-age womenImplant usersHormone metabolismPersonalized medicine approachVariant allele frequencyOvulatory suppressionEtonogestrel implantsMass indexHormonal contraceptionConcomitant useWomen's healthPg/Medicine approachParticipant characteristicsSteroid hormonesEnzyme inducersPharmacogenomic investigations
2018
Ongoing Etonogestrel Contraceptive Implant Use Throughout Pregnancy
Lazorwitz A, Coleman-Minahan K, Teal S, Guiahi M. Ongoing Etonogestrel Contraceptive Implant Use Throughout Pregnancy. Journal Of Adolescent Health 2018, 63: 363-364. PMID: 30076014, DOI: 10.1016/j.jadohealth.2018.03.021.Peer-Reviewed Original ResearchConceptsContraceptive implantsPostpartum contraceptive methodAdverse pregnancy outcomesContraceptive implant useNeonatal outcomesPregnancy outcomesImplant exposureTeratogenic riskCase reportFavorable outcomeContraceptive methodsPharmacologic literatureClinical observationsImplant usePregnancyOutcomesImplantsNulligravidaEtonogestrelPatientsMore data