2024
The influence of lifestyle factors on serum etonogestrel concentrations among contraceptive implant users
Lazorwitz A, Sheeder J, Teal S. The influence of lifestyle factors on serum etonogestrel concentrations among contraceptive implant users. Contraception 2024, 140: 110539. PMID: 39002624, PMCID: PMC11588555, DOI: 10.1016/j.contraception.2024.110539.Peer-Reviewed Original ResearchContraceptive implant usersSerum etonogestrel concentrationsEtonogestrel concentrationsImplant usersEtonogestrel implant usersSteady-state pharmacokineticsLifestyle factorsIncreased caloric intakeInfluence of lifestyle factorsCaloric intakeSubstance useCross-sectional analysisEtonogestrelCurrent dietInconsistent associationsExercise habitsAssociationDietPharmacokineticsExerciseSerumSurvey responsesIntake
2022
P079Etonogestrel contraceptive implant users can experience breakthrough ovulation with only two weeks of exposure to a strong cyp3a inducer
Lazorwitz A, Teal S, Sheeder J. P079Etonogestrel contraceptive implant users can experience breakthrough ovulation with only two weeks of exposure to a strong cyp3a inducer. Contraception 2022, 116: 92. DOI: 10.1016/j.contraception.2022.09.103.Peer-Reviewed Original ResearchStrong CYP3A inducersBreakthrough ovulationCYP3A inducersE2 concentrationsP4 concentrationsMedian ageOvulation suppressionImplant usersPg/Baseline serum concentrationsContraceptive implant usersEtonogestrel implant usersSerum E2 concentrationsParticipants' median ageSerum P4 concentrationsENG implant usersDrug-drug interactionsRifampin exposureMedian durationENG implantMedian BMIEndogenous estradiolSerum concentrationsSurrogate biomarkerWeeks of exposure
2021
Variability in repeat serum etonogestrel concentrations among contraceptive implant users during the steady-release pharmacokinetic period
Lazorwitz A, Sheeder J, Teal S. Variability in repeat serum etonogestrel concentrations among contraceptive implant users during the steady-release pharmacokinetic period. Contraception 2021, 108: 65-68. PMID: 34973207, PMCID: PMC9011406, DOI: 10.1016/j.contraception.2021.12.008.Peer-Reviewed Original ResearchConceptsSerum etonogestrel concentrationsContraceptive implant usersEtonogestrel concentrationsImplant usersEtonogestrel implant usersSingle-time measurementsEtonogestrel implantsPharmacokinetic outcomesRepeated measures testSmall studyPharmacokinetic measurementsTime pointsPharmacokinetic studyConfidence intervalsMeasures studyImplant studiesMeasures testEtonogestrel
2017
The effect of carbamazepine on etonogestrel concentrations in contraceptive implant users
Lazorwitz A, Davis A, Swartz M, Guiahi M. The effect of carbamazepine on etonogestrel concentrations in contraceptive implant users. Contraception 2017, 95: 571-577. PMID: 28288788, DOI: 10.1016/j.contraception.2017.03.004.Peer-Reviewed Original ResearchConceptsEtonogestrel concentrationsEtonogestrel contraceptive implantCarbamazepine coadministrationFollicle-like structuresOvulatory suppressionEndometrial thicknessMean ageContraceptive implantsPg/Contraceptive implant usersEtonogestrel implant usersSerum etonogestrel concentrationsReproductive-age womenBody mass indexRisk of pregnancyEffects of carbamazepineImplant usersParticipants' mean ageImpact of carbamazepineEtonogestrel levelsMedian durationPharmacodynamic changesTransvaginal ultrasoundMajority of participantsMass index