TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Loganathan S, Wilson B, Carey S, Manzo E, Joardar A, Ugur B, Zarnescu D. TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS. Metabolites 2022, 12: 101. PMID: 35208176, PMCID: PMC8876928, DOI: 10.3390/metabo12020101.Peer-Reviewed Original ResearchAmyotrophic lateral sclerosisTDP-43 proteinopathyTDP-43Dopamine levelsMotor neuronsMetabolic alterationsModel of ALSMetabolic changesTDP-43 expressionMotor neuron diseaseComplex neurodegenerative disorderGlobal metabolomic profilingTDP-43 aggregationALS patientsDietary interventionDopamine agonistsGlucose toleranceInsulin resistanceNeuron diseaseNeurotransmitter levelsSelective degenerationTricarboxylic acid cycle metabolitesLateral sclerosisLocomotor functionLocomotor dysfunction