Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice
Zhong C, Yang J, Deng K, Lang X, Zhang J, Li M, Qiu L, Zhong G, Yu J. Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. Molecules 2023, 28: 7527. PMID: 38005247, PMCID: PMC10673355, DOI: 10.3390/molecules28227527.Peer-Reviewed Original ResearchConceptsAMP-activated protein kinaseNLRP3 inflammasome activationInflammasome activationReduction of mitochondrial reactive oxygen speciesMitochondrial reactive oxygen speciesMultiprotein signaling complexesMitochondrial membrane potentialImprovement of mitochondrial membrane potentialNLRP3-related diseasesAmeliorating mitochondrial damageSignaling complexProtein kinaseReactive oxygen speciesRegulating NLRP3 inflammasome activationNLRP3 inflammasomeMitochondrial damageInnate immunityDysregulated NLRP3 inflammasome activationAttenuated NLRP3 inflammasome activationNOD-like receptor family pyrin domainMembrane potentialOxygen speciesPyrin domainFamily pyrin domainDietary plantsPulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization
Yang X, Wu M, Yan X, Zhang C, Luo Y, Yu J. Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization. Molecules 2023, 28: 3682. PMID: 37175092, PMCID: PMC10179893, DOI: 10.3390/molecules28093682.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesAnti-tumor effectsM2 macrophage polarizationAnti-tumor activityB16-F0 cellsPolarization of M2 macrophagesTumor progressionMacrophage polarizationExpression of M2 marker genesIn vivoM2 macrophagesConditioned mediumLung metastasis of melanomaIn vitroPhosphorylated STAT6Bone marrow suppressionMRNA levelsMetastasis of melanomaSuppress tumor progressionDown-regulationMarrow-derived macrophagesMetastasis of tumorsSTAT6 signaling pathwayMarrow suppressionM2 marker genes