Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice
Zhong C, Yang J, Deng K, Lang X, Zhang J, Li M, Qiu L, Zhong G, Yu J. Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. Molecules 2023, 28: 7527. PMID: 38005247, PMCID: PMC10673355, DOI: 10.3390/molecules28227527.Peer-Reviewed Original ResearchConceptsAMP-activated protein kinaseNLRP3 inflammasome activationInflammasome activationReduction of mitochondrial reactive oxygen speciesMitochondrial reactive oxygen speciesMultiprotein signaling complexesMitochondrial membrane potentialImprovement of mitochondrial membrane potentialNLRP3-related diseasesAmeliorating mitochondrial damageSignaling complexProtein kinaseReactive oxygen speciesRegulating NLRP3 inflammasome activationNLRP3 inflammasomeMitochondrial damageInnate immunityDysregulated NLRP3 inflammasome activationAttenuated NLRP3 inflammasome activationNOD-like receptor family pyrin domainMembrane potentialOxygen speciesPyrin domainFamily pyrin domainDietary plantsTiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice
Yi X, Xu C, Yang J, Zhong C, Yang H, Tang L, Song S, Yu J. Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice. International Journal Of Molecular Sciences 2023, 24: 15556. PMID: 37958538, PMCID: PMC10648967, DOI: 10.3390/ijms242115556.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLPS-induced acute kidney injuryIntrarenal renin-angiotensin systemRenin-angiotensin systemTubular cell apoptosisAng IIKidney injuryPlasma Ang IIKidney injury markersAmeliorated renal dysfunctionCell apoptosisMale C57BL/6 miceSeveral inflammatory diseasesLPS-injected miceOxidative stressLPS-induced AKI miceLipopolysaccharide (LPS)-induced acute kidney injuryInhibiting oxidative stressRenal dysfunctionRenal expressionRenoprotective actionC57BL/6 miceRenoprotective effectsFibrosis markersInjury markers