2023
Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny
Li Y, Johnson J, Yang Y, Yu D, Kubo H, Berretta R, Wang T, Zhang X, Foster M, Yu J, Tilley D, Houser S, Chen X. Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny. AJP Heart And Circulatory Physiology 2023, 325: h702-h719. PMID: 37539452, PMCID: PMC10659327, DOI: 10.1152/ajpheart.00320.2023.Peer-Reviewed Original ResearchConceptsTransverse aortic constrictionMaternal hypothyroidismCM proliferationIn vitro studiesPressure overloadAdult heartDisease responseEffects of maternal hypothyroidismPathological remodelingHeart weightCM numbersBone morphogenetic protein 10Postnatal cardiomyocyte proliferationIn vivoBody weightProgeny of mothersCardiac pathological remodelingCardiac myocytesMyocyte proliferationPostnatal dayAortic constrictionPostnatal cardiomyocytesProtein 10Synthetic thyroxinePostnatal development
2020
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
Gannam Z, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling 2020, 13 PMID: 32843541, PMCID: PMC7569488, DOI: 10.1126/scisignal.aba3043.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric SiteAmino Acid SequenceAnimalsCell DifferentiationCell LineDual-Specificity PhosphatasesEnzyme InhibitorsFemaleHigh-Throughput Screening AssaysHumansKineticsMiceMice, KnockoutMitogen-Activated Protein Kinase PhosphatasesMyoblastsProtein BindingSequence Homology, Amino AcidSignal TransductionSmall Molecule LibrariesConceptsDystrophic muscle diseaseMitogen-activated protein kinaseMuscle diseaseTGF-β1Promising therapeutic targetP38 mitogen-activated protein kinaseTherapeutic strategiesTherapeutic targetSmall molecule inhibitionSmad2 phosphorylationDiseasePotential targetSmall-molecule screenInhibitorsTreatmentInhibition