Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice
Xu C, Yi X, Tang L, Wang H, Chu S, Yu J. Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice. American Journal Of Physiology. Renal Physiology 2023, 325: f503-f518. PMID: 37589054, DOI: 10.1152/ajprenal.00018.2023.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAngiotensin IIAnimalsAquaporin 2AutophagyChloroquineKidneyMiceReninRenin-Angiotensin SystemConceptsUrine-concentrating capabilityAquaporin-2Renal cortexAngiotensin-converting enzymeAng IIDownregulation of aquaporin-2Mechanism of autophagyEffect of autophagyRenal pathophysiologyWater deprivationRenal AQP2 expressionRenal aquaporin-2Function of autophagyRegulation of autophagyUrine-concentrating abilityRenin-angiotensin systemKidneys of miceAQP2 expressionAldosterone levelsWD miceAngiotensin IICapability of miceRapa administrationRenal medullaMice