Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice
Yi X, Xu C, Yang J, Zhong C, Yang H, Tang L, Song S, Yu J. Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice. International Journal Of Molecular Sciences 2023, 24: 15556. PMID: 37958538, PMCID: PMC10648967, DOI: 10.3390/ijms242115556.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAngiotensin IIAngiotensin-Converting Enzyme 2AnimalsFlavonoidsKidneyLipopolysaccharidesMaleMiceMice, Inbred C57BLPeptidyl-Dipeptidase ARenin-Angiotensin SystemConceptsAcute kidney injuryLPS-induced acute kidney injuryIntrarenal renin-angiotensin systemRenin-angiotensin systemTubular cell apoptosisAng IIKidney injuryPlasma Ang IIKidney injury markersAmeliorated renal dysfunctionCell apoptosisMale C57BL/6 miceSeveral inflammatory diseasesLPS-injected miceOxidative stressLPS-induced AKI miceLipopolysaccharide (LPS)-induced acute kidney injuryInhibiting oxidative stressRenal dysfunctionRenal expressionRenoprotective actionC57BL/6 miceRenoprotective effectsFibrosis markersInjury markers