Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice
Yi X, Xu C, Yang J, Zhong C, Yang H, Tang L, Song S, Yu J. Tiliroside Protects against Lipopolysaccharide-Induced Acute Kidney Injury via Intrarenal Renin–Angiotensin System in Mice. International Journal Of Molecular Sciences 2023, 24: 15556. PMID: 37958538, PMCID: PMC10648967, DOI: 10.3390/ijms242115556.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLPS-induced acute kidney injuryIntrarenal renin-angiotensin systemRenin-angiotensin systemTubular cell apoptosisAng IIKidney injuryPlasma Ang IIKidney injury markersAmeliorated renal dysfunctionCell apoptosisMale C57BL/6 miceSeveral inflammatory diseasesLPS-injected miceOxidative stressLPS-induced AKI miceLipopolysaccharide (LPS)-induced acute kidney injuryInhibiting oxidative stressRenal dysfunctionRenal expressionRenoprotective actionC57BL/6 miceRenoprotective effectsFibrosis markersInjury markersDifferential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice
Xu C, Yi X, Tang L, Wang H, Chu S, Yu J. Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice. American Journal Of Physiology. Renal Physiology 2023, 325: f503-f518. PMID: 37589054, DOI: 10.1152/ajprenal.00018.2023.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAngiotensin IIAnimalsAquaporin 2AutophagyChloroquineKidneyMiceReninRenin-Angiotensin SystemConceptsUrine-concentrating capabilityAquaporin-2Renal cortexAngiotensin-converting enzymeAng IIDownregulation of aquaporin-2Mechanism of autophagyEffect of autophagyRenal pathophysiologyWater deprivationRenal AQP2 expressionRenal aquaporin-2Function of autophagyRegulation of autophagyUrine-concentrating abilityRenin-angiotensin systemKidneys of miceAQP2 expressionAldosterone levelsWD miceAngiotensin IICapability of miceRapa administrationRenal medullaMice