2024
Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fat
2020
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis
Fu H, Sun Y, Shao Y, Saredy J, Cueto R, Liu L, Drummer C, Johnson C, Xu K, Lu Y, Li X, Meng S, Xue E, Tan J, Jhala N, Yu D, Zhou Y, Bayless K, Yu J, Rogers T, Hu W, Snyder N, Sun J, Qin X, Jiang X, Wang H, Yang X. Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis. Frontiers In Immunology 2020, 11: 595813. PMID: 33154757, PMCID: PMC7591706, DOI: 10.3389/fimmu.2020.595813.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesIL-35Ischemia-induced angiogenesisHindlimb ischemiaOmics data analysisApoE-/- controlsLoss-of-functionEndothelial cellsExtracellular matrix remodeling proteinsRegenerative angiogenesisExtracellular matrix proteinsGain-of-functionRNA-seqExtracellular matrix re-organizationIL-6STMatrix remodeling proteinsTranscriptome analysisLate phaseTube formation <i>IL-12RB2Interleukin (ILTranscriptome analysis of endothelial cellsIL-12 familyMatrix proteinsAnalysis of endothelial cells