2024
Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Chu S, Shan D, He L, Yang S, Feng Y, Zhang Y, Yu J. Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation. Frontiers In Immunology 2024, 15: 1412022. PMID: 38881898, PMCID: PMC11176519, DOI: 10.3389/fimmu.2024.1412022.Peer-Reviewed Original ResearchVascular smooth muscle cellsAbdominal aortic aneurysmVascular smooth muscle cell dedifferentiationAbdominal aortic aneurysm formationAortic aneurysmMatrix metalloproteinasesVascular smooth muscle cell transdifferentiationAbdominal aortic aneurysms ManagementExpression of matrix metalloproteinasesIncreased expression of matrix metalloproteinasesSmooth muscle cellsDecreasing vascular inflammationInflammation in vitroModel in vivoAnemoside B4Macrophage-like cellsModel in vitroAAA developmentAbnormal dilatationChronic inflammationAAA pathogenesisVascular inflammationMuscle cellsEffects of anemoside B4MMP expression
2022
Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue
Leigh T, Kawai T, Preston K, Kelemen S, Okune R, St Paul A, Corbett C, Peluzzo A, Yu J, Scalia R, Autieri M. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. American Journal Of Pathology 2022, 192: 1092-1108. PMID: 35460615, PMCID: PMC9253916, DOI: 10.1016/j.ajpath.2022.03.014.Peer-Reviewed Original ResearchConceptsLow density lipoprotein receptor adaptor protein 1Visceral adipose tissueInsulin resistanceAdipose tissueAdaptor protein 1Metabolic regulatory rolesHigh-fat Western dietComorbidities of obesityWild-type controlsGene expression signaturesIncreased plasma cholesterolReduced glucose uptakeIncreased CD36 expressionIncreased plaque burdenPreclinical modelsLipid storageChow dietRegulatory roleVascular inflammationCD36 expressionWestern dietAtherosclerotic plaque formationMetabolic profileAkt phosphorylationEnergy homeostasis