2024
Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fat
2023
Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype
Li Y, Kubo H, Yu D, Yang Y, Johnson J, Eaton D, Berretta R, Foster M, McKinsey T, Yu J, Elrod J, Chen X, Houser S. Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype. AJP Heart And Circulatory Physiology 2023, 324: h443-h460. PMID: 36763506, PMCID: PMC9988529, DOI: 10.1152/ajpheart.00594.2022.Peer-Reviewed Original ResearchConceptsSuberoylanilide hydroxamic acidHFpEF phenotypeHigh-fat dietAtrial natriuretic peptideEjection fractionHeart failureCM hypertrophyMouse modelL-NAMEMyocardial fibrosisTesting of novel therapeutic strategiesTherapeutic strategiesSuberoylanilide hydroxamic acid treatmentPathological stressorsHistone deacetylasesIncreased atrial natriuretic peptideFeatures of HFpEFL-NAME treatmentDiastolic filling pressureWild-typeNovel therapeutic strategiesMonths of high-fat dietInvasive hemodynamicsDiastolic dysfunctionWT mice
2020
An allosteric site on MKP5 reveals a strategy for small-molecule inhibition
Gannam Z, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. An allosteric site on MKP5 reveals a strategy for small-molecule inhibition. Science Signaling 2020, 13 PMID: 32843541, PMCID: PMC7569488, DOI: 10.1126/scisignal.aba3043.Peer-Reviewed Original ResearchMeSH KeywordsAllosteric SiteAmino Acid SequenceAnimalsCell DifferentiationCell LineDual-Specificity PhosphatasesEnzyme InhibitorsFemaleHigh-Throughput Screening AssaysHumansKineticsMiceMice, KnockoutMitogen-Activated Protein Kinase PhosphatasesMyoblastsProtein BindingSequence Homology, Amino AcidSignal TransductionSmall Molecule LibrariesConceptsDystrophic muscle diseaseMitogen-activated protein kinaseMuscle diseaseTGF-β1Promising therapeutic targetP38 mitogen-activated protein kinaseTherapeutic strategiesTherapeutic targetSmall molecule inhibitionSmad2 phosphorylationDiseasePotential targetSmall-molecule screenInhibitorsTreatmentInhibition