Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation
Chu S, Shan D, He L, Yang S, Feng Y, Zhang Y, Yu J. Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation. Frontiers In Immunology 2024, 15: 1412022. PMID: 38881898, PMCID: PMC11176519, DOI: 10.3389/fimmu.2024.1412022.Peer-Reviewed Original ResearchVascular smooth muscle cellsAbdominal aortic aneurysmVascular smooth muscle cell dedifferentiationAbdominal aortic aneurysm formationAortic aneurysmMatrix metalloproteinasesVascular smooth muscle cell transdifferentiationAbdominal aortic aneurysms ManagementExpression of matrix metalloproteinasesIncreased expression of matrix metalloproteinasesSmooth muscle cellsDecreasing vascular inflammationInflammation in vitroModel in vivoAnemoside B4Macrophage-like cellsModel in vitroAAA developmentAbnormal dilatationChronic inflammationAAA pathogenesisVascular inflammationMuscle cellsEffects of anemoside B4MMP expression