2024
Edgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury
Lang X, Zhong C, Su L, Qin M, Xie Y, Shan D, Cui Y, Shi M, Li M, Quan H, Qiu L, Zhong G, Yu J. Edgeworthia gardneri (Wall.) Meisn. Ethanolic Extract Attenuates Endothelial Activation and Alleviates Cardiac Ischemia-Reperfusion Injury. Molecules 2024, 29: 1068. PMID: 38474581, PMCID: PMC10935089, DOI: 10.3390/molecules29051068.Peer-Reviewed Original ResearchConceptsExtracellular regulated protein kinasesEndothelium activationMitogen-activated protein kinaseI/R injuryEndothelial cellsCardiac ischemia-reperfusion injuryIschemia-reperfusion (I/RAdhesion to endothelial cellsIschemia-reperfusion injuryExpression of pro-inflammatory mediatorsNuclear factor kappa BCardiac I/R injuryPro-inflammatory mediatorsIn vivo findingsP38 mitogen-activated protein kinaseFactor kappa BPro-inflammatory activityI/R-induced inflammationMyocardial I/R injuryEndothelial activationCardiac injuryC-Jun <i>N</i>-terminal kinase (JTherapeutic efficacyFirm adhesion to endothelial cellsProtein kinase
2023
Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice
Zhong C, Yang J, Deng K, Lang X, Zhang J, Li M, Qiu L, Zhong G, Yu J. Tiliroside Attenuates NLRP3 Inflammasome Activation in Macrophages and Protects against Acute Lung Injury in Mice. Molecules 2023, 28: 7527. PMID: 38005247, PMCID: PMC10673355, DOI: 10.3390/molecules28227527.Peer-Reviewed Original ResearchConceptsAMP-activated protein kinaseNLRP3 inflammasome activationInflammasome activationReduction of mitochondrial reactive oxygen speciesMitochondrial reactive oxygen speciesMultiprotein signaling complexesMitochondrial membrane potentialImprovement of mitochondrial membrane potentialNLRP3-related diseasesAmeliorating mitochondrial damageSignaling complexProtein kinaseReactive oxygen speciesRegulating NLRP3 inflammasome activationNLRP3 inflammasomeMitochondrial damageInnate immunityDysregulated NLRP3 inflammasome activationAttenuated NLRP3 inflammasome activationNOD-like receptor family pyrin domainMembrane potentialOxygen speciesPyrin domainFamily pyrin domainDietary plants