Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue
Leigh T, Kawai T, Kelemen S, Okune R, Preston K, St. Paul A, Corbett C, Yu J, Scalia R, Autieri M. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5079.Peer-Reviewed Original ResearchLow density lipoprotein receptor adaptor protein 1Autosomal recessive hypercholesterolemiaHigh-fat Western dietInsulin resistanceAdaptor protein 1Metabolic regulatory rolesAdipose tissueReduced glucose uptakeGene expression signaturesWhite adipose tissuePre-clinical modelsCo-morbidities of obesityWild-type controlsIncreased plasma cholesterolLipid storageIncreased CD36 expressionRegulatory roleIncreased plaque burdenReceptor malfunctionAkt phosphorylationEnergy homeostasisGlucose uptakeProtein 1Co-morbiditiesChow diet