Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fat