Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue
Leigh T, Kawai T, Kelemen S, Okune R, Preston K, St. Paul A, Corbett C, Yu J, Scalia R, Autieri M. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5079.Peer-Reviewed Original ResearchLow density lipoprotein receptor adaptor protein 1Autosomal recessive hypercholesterolemiaHigh-fat Western dietInsulin resistanceAdaptor protein 1Metabolic regulatory rolesAdipose tissueReduced glucose uptakeGene expression signaturesWhite adipose tissuePre-clinical modelsCo-morbidities of obesityWild-type controlsIncreased plasma cholesterolLipid storageIncreased CD36 expressionRegulatory roleIncreased plaque burdenReceptor malfunctionAkt phosphorylationEnergy homeostasisGlucose uptakeProtein 1Co-morbiditiesChow dietDeletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue
Leigh T, Kawai T, Preston K, Kelemen S, Okune R, St Paul A, Corbett C, Peluzzo A, Yu J, Scalia R, Autieri M. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. American Journal Of Pathology 2022, 192: 1092-1108. PMID: 35460615, PMCID: PMC9253916, DOI: 10.1016/j.ajpath.2022.03.014.Peer-Reviewed Original ResearchConceptsLow density lipoprotein receptor adaptor protein 1Visceral adipose tissueInsulin resistanceAdipose tissueAdaptor protein 1Metabolic regulatory rolesHigh-fat Western dietComorbidities of obesityWild-type controlsGene expression signaturesIncreased plasma cholesterolReduced glucose uptakeIncreased CD36 expressionIncreased plaque burdenPreclinical modelsLipid storageChow dietRegulatory roleVascular inflammationCD36 expressionWestern dietAtherosclerotic plaque formationMetabolic profileAkt phosphorylationEnergy homeostasis