Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny
Li Y, Johnson J, Yang Y, Yu D, Kubo H, Berretta R, Wang T, Zhang X, Foster M, Yu J, Tilley D, Houser S, Chen X. Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny. AJP Heart And Circulatory Physiology 2023, 325: h702-h719. PMID: 37539452, PMCID: PMC10659327, DOI: 10.1152/ajpheart.00320.2023.Peer-Reviewed Original ResearchConceptsTransverse aortic constrictionMaternal hypothyroidismCM proliferationIn vitro studiesPressure overloadAdult heartDisease responseEffects of maternal hypothyroidismPathological remodelingHeart weightCM numbersBone morphogenetic protein 10Postnatal cardiomyocyte proliferationIn vivoBody weightProgeny of mothersCardiac pathological remodelingCardiac myocytesMyocyte proliferationPostnatal dayAortic constrictionPostnatal cardiomyocytesProtein 10Synthetic thyroxinePostnatal developmentPulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization
Yang X, Wu M, Yan X, Zhang C, Luo Y, Yu J. Pulsatilla Saponins Inhibit Experimental Lung Metastasis of Melanoma via Targeting STAT6-Mediated M2 Macrophages Polarization. Molecules 2023, 28: 3682. PMID: 37175092, PMCID: PMC10179893, DOI: 10.3390/molecules28093682.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesAnti-tumor effectsM2 macrophage polarizationAnti-tumor activityB16-F0 cellsPolarization of M2 macrophagesTumor progressionMacrophage polarizationExpression of M2 marker genesIn vivoM2 macrophagesConditioned mediumLung metastasis of melanomaIn vitroPhosphorylated STAT6Bone marrow suppressionMRNA levelsMetastasis of melanomaSuppress tumor progressionDown-regulationMarrow-derived macrophagesMetastasis of tumorsSTAT6 signaling pathwayMarrow suppressionM2 marker genes