Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis
Fu H, Sun Y, Shao Y, Saredy J, Cueto R, Liu L, Drummer C, Johnson C, Xu K, Lu Y, Li X, Meng S, Xue E, Tan J, Jhala N, Yu D, Zhou Y, Bayless K, Yu J, Rogers T, Hu W, Snyder N, Sun J, Qin X, Jiang X, Wang H, Yang X. Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis. Frontiers In Immunology 2020, 11: 595813. PMID: 33154757, PMCID: PMC7591706, DOI: 10.3389/fimmu.2020.595813.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesIL-35Ischemia-induced angiogenesisHindlimb ischemiaOmics data analysisApoE-/- controlsLoss-of-functionEndothelial cellsExtracellular matrix remodeling proteinsRegenerative angiogenesisExtracellular matrix proteinsGain-of-functionRNA-seqExtracellular matrix re-organizationIL-6STMatrix remodeling proteinsTranscriptome analysisLate phaseTube formation <i>IL-12RB2Interleukin (ILTranscriptome analysis of endothelial cellsIL-12 familyMatrix proteinsAnalysis of endothelial cells