PGE2 stimulates aldosterone release via cAMP/sPRR/β-catenin pathway in mouse inner medullary collecting duct cells
Xu C, Yi X, Qin M, Chu S, Liu C, Xiong J, Ouyang X, Yu J. PGE2 stimulates aldosterone release via cAMP/sPRR/β-catenin pathway in mouse inner medullary collecting duct cells. The Journal Of Steroid Biochemistry And Molecular Biology 2023, 225: 106205. DOI: 10.1016/j.jsbmb.2022.106205.Peer-Reviewed Original ResearchProstaglandin E2Aldosterone releaseCollecting ductsSoluble PRRE-prostanoidProtein kinase CE-prostanoid (EP) receptorsInner medullary collecting duct cellsMedullary collecting duct cellsAction of prostaglandin E2Adrenal zona glomerulosa cellsMouse inner medullary collecting duct cellsProtein kinase A inhibitor H89CD cellsZona glomerulosa cellsRelease of aldosteroneEP1 receptorGlomerulosa cellsSynthesis of aldosteroneSC-19220Angiotensin IIAldosteroneNa+ depletionProrenin/reninCAMP levels