Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype
Li Y, Kubo H, Yu D, Yang Y, Johnson J, Eaton D, Berretta R, Foster M, McKinsey T, Yu J, Elrod J, Chen X, Houser S. Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype. AJP Heart And Circulatory Physiology 2023, 324: h443-h460. PMID: 36763506, PMCID: PMC9988529, DOI: 10.1152/ajpheart.00594.2022.Peer-Reviewed Original ResearchConceptsSuberoylanilide hydroxamic acidHFpEF phenotypeHigh-fat dietAtrial natriuretic peptideEjection fractionHeart failureCM hypertrophyMouse modelL-NAMEMyocardial fibrosisTesting of novel therapeutic strategiesTherapeutic strategiesSuberoylanilide hydroxamic acid treatmentPathological stressorsHistone deacetylasesIncreased atrial natriuretic peptideFeatures of HFpEFL-NAME treatmentDiastolic filling pressureWild-typeNovel therapeutic strategiesMonths of high-fat dietInvasive hemodynamicsDiastolic dysfunctionWT mice