2024
Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation
Zhao S, Guo H, Qiu L, Zhong C, Xue J, Qin M, Zhang Y, Xu C, Xie Y, Yu J. Saponins from Allii Macrostemonis Bulbus attenuate atherosclerosis by inhibiting macrophage foam cell formation and inflammation. Scientific Reports 2024, 14: 12917. PMID: 38839811, PMCID: PMC11153636, DOI: 10.1038/s41598-024-61209-w.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesMarrow-derived macrophagesFoam cell formationMacrophage foam cell formationLipid-loweringCell formationApolipoprotein E-deficientHigh-fat diet feedingInhibit macrophage foam cell formationClinical management of atherosclerosisAtherosclerosis plaque formationAnti-atherosclerotic effectsAnti-inflammatory propertiesManagement of atherosclerosisClinical managementAttenuate inflammationLPS-induced inflammatory responseAllii Macrostemonis BulbusCD36 expressionTherapeutic strategiesIn vitro experimentsInflammatory responseAnti-coagulationE deficiencyHigh-fat
2022
Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue
Leigh T, Kawai T, Preston K, Kelemen S, Okune R, St Paul A, Corbett C, Peluzzo A, Yu J, Scalia R, Autieri M. Deletion of LDLRAP1 Induces Atherosclerotic Plaque Formation, Insulin Resistance, and Dysregulated Insulin Response in Adipose Tissue. American Journal Of Pathology 2022, 192: 1092-1108. PMID: 35460615, PMCID: PMC9253916, DOI: 10.1016/j.ajpath.2022.03.014.Peer-Reviewed Original ResearchConceptsLow density lipoprotein receptor adaptor protein 1Visceral adipose tissueInsulin resistanceAdipose tissueAdaptor protein 1Metabolic regulatory rolesHigh-fat Western dietComorbidities of obesityWild-type controlsGene expression signaturesIncreased plasma cholesterolReduced glucose uptakeIncreased CD36 expressionIncreased plaque burdenPreclinical modelsLipid storageChow dietRegulatory roleVascular inflammationCD36 expressionWestern dietAtherosclerotic plaque formationMetabolic profileAkt phosphorylationEnergy homeostasis