Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice
Xu C, Yi X, Tang L, Wang H, Chu S, Yu J. Differential regulation of autophagy on urine-concentrating capability through modulating the renal AQP2 expression and renin-angiotensin system in mice. American Journal Of Physiology. Renal Physiology 2023, 325: f503-f518. PMID: 37589054, DOI: 10.1152/ajprenal.00018.2023.Peer-Reviewed Original ResearchConceptsUrine-concentrating capabilityAquaporin-2Renal cortexAngiotensin-converting enzymeAng IIDownregulation of aquaporin-2Mechanism of autophagyEffect of autophagyRenal pathophysiologyWater deprivationRenal AQP2 expressionRenal aquaporin-2Function of autophagyRegulation of autophagyUrine-concentrating abilityRenin-angiotensin systemKidneys of miceAQP2 expressionAldosterone levelsWD miceAngiotensin IICapability of miceRapa administrationRenal medullaMicePGE2 stimulates aldosterone release via cAMP/sPRR/β-catenin pathway in mouse inner medullary collecting duct cells
Xu C, Yi X, Qin M, Chu S, Liu C, Xiong J, Ouyang X, Yu J. PGE2 stimulates aldosterone release via cAMP/sPRR/β-catenin pathway in mouse inner medullary collecting duct cells. The Journal Of Steroid Biochemistry And Molecular Biology 2023, 225: 106205. DOI: 10.1016/j.jsbmb.2022.106205.Peer-Reviewed Original ResearchProstaglandin E2Aldosterone releaseCollecting ductsSoluble PRRE-prostanoidProtein kinase CE-prostanoid (EP) receptorsInner medullary collecting duct cellsMedullary collecting duct cellsAction of prostaglandin E2Adrenal zona glomerulosa cellsMouse inner medullary collecting duct cellsProtein kinase A inhibitor H89CD cellsZona glomerulosa cellsRelease of aldosteroneEP1 receptorGlomerulosa cellsSynthesis of aldosteroneSC-19220Angiotensin IIAldosteroneNa+ depletionProrenin/reninCAMP levels