The Zaidi Lab is dedicated to uncovering the principles of cancer biology, with a focus on how tumors and their ecosystems evolve to drive therapy resistance. We integrate genetic engineering, advanced mouse and human model systems, and bioinformatics to investigate fundamental questions about cancer cell plasticity and its impact on the tumor microenvironment.
Our research program focuses on how tumors interact with surrounding immune cells and fibroblasts to drive therapeutic resistance. We use a diverse array of tools—including genomic and immunologic approaches—to study these interactions in both in vitro and in vivo settings, leveraging dynamic model systems. To ensure clinical relevance and anticipate therapeutic benefit, we benchmark our findings against biologic data derived from human tumors.
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