Malini Harigopal, MD
Professor Adjunct in PathologyDownloadHi-Res Photo
Cards
Appointments
Pathology
Primary
Additional Titles
Director of Immunohistochemistry Lab, Pathology
Contact Info
Appointments
Pathology
Primary
Additional Titles
Director of Immunohistochemistry Lab, Pathology
Contact Info
Appointments
Pathology
Primary
Additional Titles
Director of Immunohistochemistry Lab, Pathology
Contact Info
About
Titles
Professor Adjunct in Pathology
Director of Immunohistochemistry Lab, Pathology
Biography
Dr. Harigopal completed her residency in Anatomic and Clinical Pathology at the University of Chicago in 2001, followed by a fellowship in cytopathology at New York Presbyterian Hospital. Dr. Harigopal also completed fellowships in breast pathology, cytopathology and renal pathology at New York Presbyterian. She is a board-certified cytopathologist.
Appointments
Pathology
Professor AdjunctPrimary
Other Departments & Organizations
- Center for Breast Cancer
- Cytopathology
- Pancreatic Diseases Program
- Pathology
- Pathology and Molecular Medicine
- Surgical Pathology
- Yale Cancer Center
- Yale Ventures
Education & Training
- Fellow
- New York Presbyterian Hospital (2016)
- Fellow
- New York Presbyterian Hospital (2002)
- Fellow
- New York Presbyterian Hospital (2001)
- Resident
- University of Chicago Medical Center (2000)
- Resident
- Brooklyn Hospital (1997)
- MD
- Gandhi Medical College (1985)
Research
Overview
Biomarker studies in breast cancer and pancreatic cancers using an objective and quantitative method of analysis (AQUA) in tissue microarrays.
Medical Research Interests
Breast; Breast Neoplasms; Immunohistochemistry; Microarray Analysis; Pathology; Thyroid Gland
Research at a Glance
Yale Co-Authors
Frequent collaborators of Malini Harigopal's published research.
Publications Timeline
A big-picture view of Malini Harigopal's research output by year.
Research Interests
Research topics Malini Harigopal is interested in exploring.
David Rimm, MD, PhD
Angelique W. Levi, MD
Peter Podany
Liva Andrejeva-Wright, MD
Robert Camp, PhD, MD
Lajos Pusztai, MD, DPhil
106Publications
3,576Citations
Breast Neoplasms
Immunohistochemistry
Thyroid Gland
Breast
Publications
2024
Architectural Distortions
Butler R, Durand M, Lanjevar S, Podany P, Andrejeva L, Harigopal M. Architectural Distortions. 2024, 185-207. DOI: 10.1007/978-3-031-65711-5_7.Peer-Reviewed Original ResearchConceptsInvasive lobular carcinomaLikelihood of malignancyRadial sclerosing lesionsLobular carcinomaSclerosing lesionsTubular carcinomaArchitectural distortionBenign entityDegree of proliferative changeRadial scar/complex sclerosing lesionDuctal carcinoma in situCarcinoma in situInvasive ductal carcinomaChance of malignancyIncidental microscopic findingAbsence of enhancementPost-contrast imagesMyoepithelial cell layerEntrapped glandsField digital mammographyDiscohesive cellsSonographic correlateDuctal carcinomaInvasive carcinomaPalpable massComplex Cystic and Solid Masses
Harigopal M, Cole K, Podany P, Verma A, Andrejeva L. Complex Cystic and Solid Masses. 2024, 57-95. DOI: 10.1007/978-3-031-65711-5_3.Peer-Reviewed Original ResearchConceptsCystic lesionsSolid massAspiration of cystsBenign papillary tumorsPapillary apocrine metaplasiaCore needle biopsyComplex cystic lesionsMalignant cystic lesionsPresence of calcificationLeakage of cyst contentsFindingsThe vast majorityPapillary tumorsApocrine carcinomaPapillary carcinomaDuctal carcinomaNipple dischargeCystic componentNeedle biopsyApocrine metaplasiaDuct ectasiaBenign lesionsReactive lesionsComplicated cystsPerimenopausal womenFat necrosisDiscordances Between Radiology and Pathology
Harigopal M, Verma A, Andrejeva L, Lewin J. Discordances Between Radiology and Pathology. 2024, 375-391. DOI: 10.1007/978-3-031-65711-5_14.Peer-Reviewed Original ResearchConceptsPathological findingsImaging characteristicsMRI-guided biopsyFalse-negative diagnosesRadiology-pathology correlationH&E levelsPreoperative biopsyStereotactic biopsySurgical excisionPercutaneous biopsyDiscordant casesSonographic guidanceBreast biopsyAncillary stainsHistopathological findingsBiopsyMammographic lesionsLesionsIndividual pathologistsPathologistsPotential causesUltrasoundWeekly conferencesImage featuresDiscordanceRare Breast Tumors
Harigopal M, Podany P, Andrejeva L, Singh K. Rare Breast Tumors. 2024, 343-374. DOI: 10.1007/978-3-031-65711-5_13.Peer-Reviewed Original ResearchConceptsSubtypes of breast cancerBreast cancerRare subtypeWorld Health OrganizationRare subtype of breast cancerHistological subtype of breast cancerWorld Health Organization Classification of TumorsCore needle biopsy specimensWorld Health Organization classificationTall cell carcinomaNeedle biopsy specimensRare histologic typeClassification of tumorsRare cancer typesRare tumorHistological subtypesHistological typeCell carcinomaUnusual subtypeBiopsy specimensPrognostic implicationsGenetic alterationsHistological featuresHistologic cluesAncillary testsCircumscribed Masses
Harigopal M, Raghu M, Pham R, Rende A, Podany P, Andrejeva L. Circumscribed Masses. 2024, 11-55. DOI: 10.1007/978-3-031-65711-5_2.Peer-Reviewed Original ResearchConceptsTerminal duct lobular unitsEncapsulated papillary carcinomaInvasive ductal carcinomaCircumscribed massFibroepithelial neoplasmsStromal componentsScreening mammographyPhyllodes tumorFibroepithelial lesionsPapillary carcinomaDuctal carcinomaInvasive carcinomaComplicated cystsCellular fibroadenomaHigh-grade invasive ductal carcinomaBI-RADSDuctal carcinoma in situOuter layer of myoepithelial cellsAggressive breast malignancyBasal-like carcinomasBenign fibroepithelial lesionsBenign fibroepithelial neoplasmBorderline phyllodes tumorMalignant phyllodes tumorSmooth muscle metaplasiaSpiculated Masses
Harigopal M, Andrejeva L, Lanjewar S, Podany P. Spiculated Masses. 2024, 127-158. DOI: 10.1007/978-3-031-65711-5_5.Peer-Reviewed Original ResearchConceptsInvasive ductal carcinomaInvasive lobular carcinomaDuctal carcinoma in situLobular carcinomaDuctal carcinomaSpiculated massesTumor cellsBenign entitySclerosing adenosisCorrelation of imaging findingsDesmoplastic stromal responseDiscohesive tumor cellsCore needle biopsyPseudoangiomatous stromal hyperplasiaCarcinoma in situInvasive mammary carcinomaFalse-negative mammogramsGranular cell tumorInvasive tumor cellsDiabetic mastopathyMucinous carcinomaStromal hyperplasiaInvasive cancerPleomorphic calcificationsDesmoplastic stromaIntroduction and General Consideration of Radiology-Pathology Correlation
Harigopal M, Andrejeva L, Podany P, Lewin J, Raghu M, Singh K. Introduction and General Consideration of Radiology-Pathology Correlation. 2024, 1-9. DOI: 10.1007/978-3-031-65711-5_1.Peer-Reviewed Original ResearchConceptsFull-field digital mammographyInterval cancer rateIncreased cancer detection ratesCancer detection rateScreen-film mammographyCancer ratesBreast pathologistsYears of experiencePatient careNational expertsMultidisciplinary meetingComplex exerciseCore needle biopsyDiagnosis of breast lesionsDigital mammographyMammographyField of radiologyRadiology-pathology correlationTissue samplesRadiology reportsBreastAccurate diagnosis of breast lesionsCharacterization of lesionsBreast tissue samplesBreast imagingMasses with Indistinct Margins
Singh K, Lee J, Harigopal M, Andrejeva L. Masses with Indistinct Margins. 2024, 97-125. DOI: 10.1007/978-3-031-65711-5_4.Peer-Reviewed Original ResearchSkin Thickening and Vascular Lesions
Andrejeva L, Lanjewar S, Woolf G, Killelea B, Brownson K, Podany P, Harigopal M. Skin Thickening and Vascular Lesions. 2024, 297-323. DOI: 10.1007/978-3-031-65711-5_11.Peer-Reviewed Original ResearchConceptsRare group of neoplasmsInflammatory breast carcinomaInvasive lobular carcinomaMalignant vascular tumorsGroup of neoplasmsIll-defined marginsLobular carcinomaBreast carcinomaBenign tumorsClinical presentationBenign lesionsVascular tumorsBreast parenchymaClinical historyWell-circumscribedSkin thickeningMalignant processVascular lesionsRare groupImaging appearanceSubcutaneous tissueContrast enhancementBreastCarcinomaTumorClinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer.
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 10668969241256109. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchAltmetricConceptsBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival time
Academic Achievements & Community Involvement
honor HPV Investigation Award
National AwardAmerican Society of CytopathologyDetails08/29/2016United Statesactivity Papanikolaou Society
Professional OrganizationsMemberDetailsEducation committee for national residency and cytotechnology programs07/31/2014 - 08/29/2016
News
News
- May 31, 2022
Uma Krishnamurti, MBBS, MD, PhD, Named New Director of Yale Breast Pathology
- October 13, 2021
Breast Cancer Awareness Q&A with Pathologist Malini Harigopal, MD
- May 29, 2020Source: Nature Medicine
Nature Medicine's COVID-19 Research in Brief: 9 May to 15 May, 2020
- June 01, 2015
Breast cancer study finds it helps to remove more tissue
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Locations
Department of Pathology
Academic Office
Clinic Building
789 Howard Avenue, Ste CB 505A
New Haven, CT 06519
Fax
203.785.2641Appointments
203.785.3753