2021
Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling
Zhang L, Lin TV, Yuan Q, Sadoul R, Lam TT, Bordey A. Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling. Journal Of Neuroscience 2021, 41: 3799-3807. PMID: 33741723, PMCID: PMC8084316, DOI: 10.1523/jneurosci.0766-20.2021.Peer-Reviewed Original ResearchConceptsSmall extracellular vesiclesRegulation of HDAC2Extracellular vesiclesSpine developmentCell-cell signalingTranscriptional programsCortical neuronsSEV releaseTranscriptional decreaseDendritic spinesNeuronal developmentNeuron developmentDendritic spine developmentLines of evidenceHDAC2Paracrine communicationAge-dependent decreaseVesiclesPopulations of neuronsRegulationLC-MS/MSHDAC2 levelsSynaptic targetsExcitatory synapsesSpine growth
2009
GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches
Young SZ, Bordey A. GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches. Physiology 2009, 24: 171-185. PMID: 19509127, PMCID: PMC2931807, DOI: 10.1152/physiol.00002.2009.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStem cellsGamma-amino butyric acidProliferation of pluripotentAdult stem cellsNeural stem cellsAdult tissuesCancer cell proliferationRegulation of secretionTumor stem cellsTumor cellsCell proliferationAdult neuralProliferationCellsGABA controlPeripheral organsGABAergic signalingPeripheral nichesNervous systemMitotic activityPluripotentButyric acidNicheSignalingRegulation