Structural dynamics of kappa opioid receptor interactions with β-arrestin 1
Han J, Fine E, Jiang Q, Zhuang Y, Suomivuori C, Chen Z, Denn E, Whiddon K, Li K, Evers A, Fuller J, Carter J, Fay J, Chen M, Dror R, Che T. Structural dynamics of kappa opioid receptor interactions with β-arrestin 1. Nature Communications 2026 PMID: 42243110, DOI: 10.1038/s41467-026-73968-3.Peer-Reviewed Original Research
Molecular dynamics simulationsOrthosteric binding siteStructural dynamicsConformational dynamicsDynamics simulationsMass spectrometry analysisStructural featuresElectron microscopyAllosteric pathwaysCryogenic electron microscopySpectrometry analysisCore interactionsKappa-opioid receptorsPhospholipid binding sitePhosphorylation sitesComplexComplex structureG protein activationB-arrestinStructureA-resolutionEffects of opiate drugsReceptor signalingOpioid receptor interactionsOpioid receptor signaling