Mingming Chen, PhD
Postdoctoral AssociateAbout
Research
Publications
2022
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z. Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway. Drug Development Research 2022, 84: 211-225. PMID: 36567664, DOI: 10.1002/ddr.22024.Peer-Reviewed Original ResearchConceptsAcute liver injuryPGC-1α pathwayLiver injuryCytochrome P450 2E1 (CYP2E1) levelsEndoplasmic reticulum stress activationOxidative stressP450 2E1 levelsImproved liver functionPotential therapeutic effectsPGC-1α levelsHepatocyte cell deathUnclear molecular mechanismsLiver functionProinflammatory cytokinesHepatic toxicityHepatoprotective effectTherapeutic effectAPAP metabolismATF4 knockdownNecrotic areasWestern blotAPAPMetabolic activationMitochondrial dysfunctionProtein levelsAstrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors
Yu G, Cao F, Hou T, Cheng Y, Jia B, Yu L, Chen W, Xu Y, Chen M, Wang Y. Astrocyte reactivation in medial prefrontal cortex contributes to obesity-promoted depressive-like behaviors. Journal Of Neuroinflammation 2022, 19: 166. PMID: 35761401, PMCID: PMC9235218, DOI: 10.1186/s12974-022-02529-4.Peer-Reviewed Original ResearchConceptsDepressive-like behaviorMedial prefrontal cortexSpontaneous inhibitory postsynaptic currentsSpontaneous excitatory postsynaptic currentsOb/ob miceEmotion-related brain regionsHigh-fat dietAstrocyte reactivationNormal diet miceNeuronal activityBrain regionsGlial reactivationHFD miceSusceptible micePostsynaptic currentsObesogenic factorsOb miceInhibitory postsynaptic currentsNeuronal electrophysiological propertiesRisk of depressionExcitatory postsynaptic currentsWild-type micePrefrontal cortex contributesGlial responseAstrocyte reactivity
2021
Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation
Cao R, Li L, Zhang W, Lu J, Wang Y, Chen Q, Zhang W, Chen M, Sheng L, Cai K, Xu G. Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation. Biochemical And Biophysical Research Communications 2021, 580: 20-27. PMID: 34607259, DOI: 10.1016/j.bbrc.2021.09.025.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain regionsCognitive improvementCognitive deficitsCognition-related brain regionsMild TBI modelMedial prefrontal cortexAstrocyte reactivationCognitive enhancementCognitive functionPrefrontal cortexDifferent brain regionsMelatonin administrationNeuronal activityClosed head injuryEarly pathological stageUse of melatoninMelatonin attenuatesBrain injuryGlial responseNeuroprotective roleTBI modelDeficitsPathological stageHead injury
2020
p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound
Chen M, Guo L, Hao J, Ni J, Lv Q, Xin X, Liao H. p75NTR Promotes Astrocyte Proliferation in Response to Cortical Stab Wound. Cellular And Molecular Neurobiology 2020, 42: 1153-1166. PMID: 33201418, DOI: 10.1007/s10571-020-01006-x.Peer-Reviewed Original ResearchConceptsCortical stab woundAstrocyte proliferationStab woundsMouse astrocytesCell cycle progressionG2/MInjury mouse modelCycle progressionCortical stabP75NTR overexpressionAstrocyte activationFunctional recoveryAstrocytic responseReceptor upregulationBrain traumaAstrocyte apoptosisBrain injuryCDK2 protein levelsMouse modelCDK2 expressionAstrocytesCell cycle entryS phaseProfound alterationsProtein levelsThe CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
Sun H, He X, Tao X, Hou T, Chen M, He M, Liao H. The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke. Journal Of Neuroinflammation 2020, 17: 171. PMID: 32473633, PMCID: PMC7260848, DOI: 10.1186/s12974-020-01845-x.Peer-Reviewed Original ResearchConceptsCD200/CD200RSpontaneous functional recoveryPro-inflammatory factor releaseFunctional recoveryMicroglia activationSynaptic plasticityFactor releaseSensorimotor functionDendritic spinesTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelCD200/CD200R pathwayAdhesive removal testSensorimotor functional recoverySensory function recoveryArtery occlusion modelSynapse-related proteinsImmune modulatory effectsInflammatory factor releaseMultiple brain disordersMechanism of actionIpsilateral cortexNeurological recoveryStroke onsetAcute phaseHippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition
Li D, Chen M, Meng T, Fei J. Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition. Journal Of Neuroinflammation 2020, 17: 109. PMID: 32264970, PMCID: PMC7140340, DOI: 10.1186/s12974-020-01799-0.Peer-Reviewed Original ResearchConceptsPostoperative cognitive dysfunctionAstrocyte activationPathological stageAstrocyte responseMicroglial activationCognitive functionSynaptic inhibitionCognitive dysfunctionNovel object recognition testHippocampal microglial activationInitial pathological stageInhibitory postsynaptic currentsSignificant microglial activationLate pathological stageEarly pathological stageMonth old miceObject recognition testMorris water mazeQuantitative polymerase chain reactionMagnetic-activated cell sortingActivated microgliaSedative dosePostsynaptic currentsPolymerase chain reactionMicrogliaNIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease
Li Y, Chen M, Zhou Y, Tang C, Zhang W, Zhong Y, Chen Y, Zhou H, Sheng L. NIK links inflammation to hepatic steatosis by suppressing PPARα in alcoholic liver disease. Theranostics 2020, 10: 3579-3593. PMID: 32206109, PMCID: PMC7069072, DOI: 10.7150/thno.40149.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEthanolFatty AcidsFatty LiverHepatocytesInflammationLiver Diseases, AlcoholicMaleMAP Kinase Kinase 1MAP Kinase Kinase 2MiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Oxidation-ReductionPhosphorylationPPAR alphaProtein Serine-Threonine KinasesSignal TransductionConceptsAlcoholic liver diseaseFatty acid oxidationAlcoholic steatosisHepatic fatty acid oxidationHepatocyte-specific deletionHepatic steatosisLiver diseasePPARα agonistAcid oxidationBinge ethanol feedingMain pathological featuresHepatic lipid accumulationEthanol-fed miceRegulation of PPARαRole of NIKALD therapyInflammatory cytokinesPathological featuresUnderlying pathogenesisPharmacological interventionsSteatosisEthanol feedingInflammationPharmacological inhibitionPPARα
2019
Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats
Sun H, Li A, Hou T, Tao X, Chen M, Wu C, Chen S, Zhu L, Liao H. Neurogenesis promoted by the CD200/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats. Brain Behavior And Immunity 2019, 82: 354-371. PMID: 31513876, DOI: 10.1016/j.bbi.2019.09.005.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCell DifferentiationCell ProliferationExercise TestHippocampusInfarction, Middle Cerebral ArteryMaleNeural Stem CellsNeurogenesisNeuronsPhysical Conditioning, AnimalPhysical ExertionRatsRats, Sprague-DawleyReceptors, ImmunologicRecovery of FunctionSignal TransductionStrokeStroke RehabilitationConceptsCD200/CD200RCognitive functional recoveryTransient middle cerebral artery occlusionFunctional recoveryTreadmill exercisePost-stroke functional recoveryMiddle cerebral artery occlusionExercise-induced neurogenesisPre-existing neuronsCerebral artery occlusionNeurotrophic factor expressionLong-term disabilityPromotion of neurogenesisNeural stem/progenitor cell proliferationCommon treatment strategyTNF-α expressionPotential therapeutic targetAugmentation of neurogenesisStem/progenitor cell proliferationPotential molecular mechanismsProgenitor cell proliferationArtery occlusionIpsilateral hippocampusCD200R expressionSubgranular zoneMicroglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice
Sheng L, Chen M, Cai K, Song Y, Yu D, Zhang H, Xu G. Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP/PS1 mice. The FASEB Journal 2019, 33: 10425-10442. PMID: 31219699, DOI: 10.1096/fj.201900527r.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceKnockdown of TREM2Microglial phagocytosisSynaptic lossSynaptic impairmentPathologic stageAlzheimer's diseasePrevents amyloidosisPS1 miceAmyloid depositionAD pathology developmentSevere amyloid depositionGreen fluorescent protein miceHigh-risk factorsSporadic Alzheimer's diseaseCell antigen-1Thymus cell antigen 1Microglial TREM2TREM2 overexpressionElectrophysiological outcomesSynaptic dysfunctionVirus infectionHippocampal overexpressionPathologic testsMyeloid cells
2013
proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus
Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H. proNGF Inhibits Neurogenesis and Induces Glial Activation in Adult Mouse Dentate Gyrus. Neurochemical Research 2013, 38: 1695-1703. PMID: 23709363, DOI: 10.1007/s11064-013-1071-7.Peer-Reviewed Original ResearchConceptsHippocampal neurogenesisMouse hippocampusAdult mouse dentate gyrusBrains of patientsMouse dentate gyrusAdult mouse hippocampusDouble-positive cellsBrdU-incorporating cellsNerve growth factorHigh-affinity receptorGlial activationSubgranular zoneNeurotrophic factorInhibits neurogenesisDentate gyrusPositive cellsNeurogenic regionsCognitive impairmentAlzheimer's diseaseHippocampusMemory deficitsProNGFNeurogenesisGrowth factorInhibitory effect