Featured Publications
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity.
Stern DF, Heffernan PA, Weinberg RA. p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Molecular And Cellular Biology 1986, 6: 1729-1740. PMID: 2878363, PMCID: PMC367701, DOI: 10.1128/mcb.6.5.1729.Peer-Reviewed Original ResearchConceptsTyrosine kinase activityEGF receptorGrowth factor receptorProto-oncogeneKinase activityNeu proto-oncogeneC-erbB geneFactor receptorPresence of tunicamycinDistinct electrophoretic mobilitiesEpidermal growth factor receptorNormal culture conditionsMajor structural alterationsTyrosine phosphorylationGene productsNeu oncogeneNormal homologsOncogeneCell linesElectrophoretic mobilityCulture conditionsGrowth factorP185ProteinReceptors
1986
p185, a Product of the neu Proto-Oncogene, Is a Receptorlike Protein Associated with Tyrosine Kinase Activity
Stern D, Heffernan P, Weinberg R. p185, a Product of the neu Proto-Oncogene, Is a Receptorlike Protein Associated with Tyrosine Kinase Activity. Molecular And Cellular Biology 1986, 6: 1729-1740. DOI: 10.1128/mcb.6.5.1729-1740.1986.Peer-Reviewed Original ResearchTyrosine kinase activityEGF receptorGrowth factor receptorProto-oncogeneKinase activityNeu proto-oncogeneC-erbB geneFactor receptorPresence of tunicamycinDistinct electrophoretic mobilitiesEpidermal growth factor receptorNormal culture conditionsMajor structural alterationsTyrosine phosphorylationGene productsNeu oncogeneNormal homologsOncogeneCell linesElectrophoretic mobilityCulture conditionsGrowth factorP185ProteinReceptorsp185, a Product of the neu Proto-Oncogene, Is a Receptorlike Protein Associated with Tyrosine Kinase Activity
Stern D, Heffernan P, Weinberg R. p185, a Product of the neu Proto-Oncogene, Is a Receptorlike Protein Associated with Tyrosine Kinase Activity. Molecular And Cellular Biology 1986, 6: 1729-1740. DOI: 10.1128/mcb.6.5.1729-1740.1986.Peer-Reviewed Original ResearchEpidermal growth factorTyrosine kinase activityEpidermal growth factor receptorNeu proto-oncogeneAssociated with tyrosine kinase activityProto-oncogeneKinase activityNeu oncogenePresence of tunicamycinTyrosine phosphorylationNormal culture conditionsGene productsC-erbB geneMutated versionGrowth factorTransformed counterpartsGrowth factor receptorCell linesStimulated degradationElectrophoretic mobilityC-erbBCulture conditionsOncogeneGenesP185Differential Responsiveness of myc- and ras-Transfected Cells to Growth Factors: Selective Stimulation of myc-Transfected Cells by Epidermal Growth Factor
Stern D, Roberts A, Roche N, Sporn M, Weinberg R. Differential Responsiveness of myc- and ras-Transfected Cells to Growth Factors: Selective Stimulation of myc-Transfected Cells by Epidermal Growth Factor. Molecular And Cellular Biology 1986, 6: 870-877. DOI: 10.1128/mcb.6.3.870-877.1986.Peer-Reviewed Original ResearchEpidermal growth factorSoft agarPlatelet-derived growth factorRas oncogeneEGF-like factorsMyc-like genesControl cellsAnchorage-independent growthPresence of epidermal growth factorPresence of platelet-derived growth factorCells to growth factorsTGF-betaRas-transfected cellsGrowth factorExogenous growth factorsResponse of cellsMYCAgarTransforming growth factor-betaOncogeneGrowth factor-betaRasDifferential responseCellsColoniesDifferential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.
Stern DF, Roberts AB, Roche NS, Sporn MB, Weinberg RA. Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor. Molecular And Cellular Biology 1986, 6: 870-877. PMID: 3022135, PMCID: PMC367587, DOI: 10.1128/mcb.6.3.870.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Polyomavirus TransformingAntigens, Viral, TumorCell DivisionCell Transformation, NeoplasticCells, CulturedEpidermal Growth FactorGenesGenes, ViralGrowth SubstancesOncogene Proteins, ViralOncogenesPeptidesPlatelet-Derived Growth FactorPolyomavirusRatsRats, Inbred F344TransfectionTransforming Growth FactorsConceptsEpidermal growth factorPlatelet-derived growth factorExogenous growth factorsSoft agarRas oncogeneGrowth factorEGF-like factorsPresence of PDGFControl cellsAnchorage-independent growthMyc-transfected cellsRas-transfected cellsPresence of EGFLike genesMYCResponsiveness of cellsGrowth factor productionOncogeneAutocrine stimulationNumerous coloniesTGF betaLack of responsivenessGenesSelective stimulationStimulatory effectOncogenes in neural tumors
Breakefield X, Stern D. Oncogenes in neural tumors. Trends In Neurosciences 1986, 9: 150-155. DOI: 10.1016/0166-2236(86)90051-2.Peer-Reviewed Original Research
1985
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
Drebin J, Link V, Stern D, Weinberg R, Greene M. Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies. Cell 1985, 41: 695-706. PMID: 2860972, DOI: 10.1016/s0092-8674(85)80050-7.Peer-Reviewed Original ResearchConceptsNIH 3T3 cellsAnchorage-independent growthAnti-p185 monoclonal antibodiesColony formationSoft agar colony formationAgar colony formationOncogene protein productGene productsNontransformed phenotypeProtein productsAntibody treatmentRas oncogeneDNA transfectionMonoclonal antibodiesNeu gene productSoft agarOncogenePhenotypeCellsP185P185 levelsNeuroblastoma linesUnrelated specificityControl antibodyNeu oncogene
1984
Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene
Drebin J, Stern D, Link V, Weinberg R, Greene M. Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene. Nature 1984, 312: 545-548. PMID: 6504162, DOI: 10.1038/312545a0.Peer-Reviewed Original ResearchConceptsNIH 3T3 cellsCell surface antigensCellular oncogenesAnimal cancer cellsNormal NIH 3T3 cellsMonoclonal antibodiesTumor-associated antigensVariety of antigensRelative molecular massCell surface determinantsNon-malignant cellsGenetic elementsDifferent histological originDNA transfectantsDNA transfectionMolecular massNeoplastic processAntibody reactivityNeoplastic cellsMalignant cellsHistological originAntigenIdentical antigensOncogeneCancer cells