Rat arterial wall retains myointimal hyperplastic potential long after arterial injury.
Sirois M, Simons M, Kuter D, Rosenberg R, Edelman E. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation 1997, 96: 1291-8. PMID: 9286961, DOI: 10.1161/01.cir.96.4.1291.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsVascular diseaseNeointimal hyperplasiaMuscle cellsMedial smooth muscle cellsBlood vesselsAccelerated vascular diseaseSingle-dose therapyPDGFR-beta expressionVascular smooth muscle cellsPlatelet-derived growth factorProliferative vascular diseasesPeriod of thrombocytopeniaArterial injuryEndothelial denudationVascular injuryPlatelet depletionIntimal hyperplasiaPharmacological modalitiesVascular healingArterial wallHyperplasiaGrowth factorNative vesselsInjuryAntisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening.
Sirois M, Simons M, Edelman E. Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening. Circulation 1997, 95: 669-76. PMID: 9024156, DOI: 10.1161/01.cir.95.3.669.Peer-Reviewed Original Research